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Accession: PRJNA289629 ID: 289629

Homo sapiens (human)

Deregulation of HIF-Responsive Demethylases Causes Synthetic Lethality Between the VHL Tumor Suppressor Gene and the EZH1 Histone Methyltransferase

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Comparison of ccRCC cells with high HIF or low HIF activity Overall design: Cells expressing control (VEC) were compared to cells with ARNT1 loss using sh/sgRNA targeting ARNT1 The samples labeled 'con' are parental Vhl-null cells and represent the 'high HIF' state. More...
AccessionPRJNA289629; GEO: GSE70767
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsChakraborty AA et al., "HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.", Sci Transl Med, 2017 Jul 12;9(398)
SubmissionRegistration date: 10-Jul-2015
Medical Oncology, Dana-Farber Cancer Institute
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments3
Publications
PubMed1
PMC1
Other datasets
BioSample3
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes3
SRA Data Details
ParameterValue
Data volume, Gbases4
Data volume, Mbytes2917

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