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Accession: PRJNA289566 ID: 289566

Homo sapiens (human)

Profile of RNAs bound by wild-type (WT) or R534H variant of DDX3 with or without Sodium Arsenite treatment [iCLIP-Seq]

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This project is a component of the Profiles of ribosome-associated mRNAs regulated by expression of wild-type (WT) or R534H variant of DDX3 with or without Sodium Arsenite treatment
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2 additional projects are components of the Profiles of ribosome-associated mRNAs regulated by expression of wild-type (WT) or R534H variant of DDX3 with or without Sodium Arsenite treatment.
66643 additional projects are related by organism.
By iCLIP-seq, we demonstrated that DDX3 binds to specific sites on 18S ribosomal RNA and to messenger RNAs at 5’ leader and guanidine-rich sequences immediately upstream of ribosome-dense regions and that arsenite treatment redistributes DDX3 binding from 5'UTR to CDS, which is attenuated by DDX3 R534H. More...
AccessionPRJNA289566; GEO: GSE70801
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsOh S et al., "Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.", Oncotarget, 2016 May 10;7(19):28169-82
SubmissionRegistration date: 11-Jul-2015
Neurology and Neurological Sciences, Stanford University School of Medicine
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments8
Publications
PubMed1
PMC1
Other datasets
BioSample8
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes17
SRA Data Details
ParameterValue
Data volume, Gbases19
Data volume, Mbytes12163

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