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1 additional project is a component of the KDM5 occupancy and expression profiling of kdm5 mutant flies and wt flies under normal condition and oxidative stress.
Comparing the transcriptome of wildtype and kdm5 mutant flies in normal conditions revealed a total of 4787 genes that were significantly downregulated and thus require KDM5 for their activation, and 3269 upregulated genes that are normally repressed by KDM5 (p<0.05, FDR <0.05). Because kdm5 mutants are sensitive to the oxidizer paraquat, we also carried out RNA-seq from wildtype and kdm5 mutant adults in oxidative stress conditions. Paraquat treatment of wildtype flies lead to the upregulation of 2481, and downregulation of 3103 genes
Overall design: adult mRNA profiles of 1-3-days old wild type (WT) and kdm5 mutant under normal condition and oxitative stress were generated by deep sequencing, using Illumina HisSeq 2000.
| Accession | PRJNA289117; GEO: GSE70590 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Drosophila melanogaster[Taxonomy ID: 7227] Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora; Drosophila melanogaster |
| Publications | Liu X et al., "The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif.", Cell Rep, 2015 Dec 15;13(10):2219-31 |
| Submission | Registration date: 7-Jul-2015
Julie secombe, Genetics, Albert einstein college of medicne |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 4 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 4 |
| GEO DataSets | 1 |