See
Genome Information for Mus musculus
While LPS as expected induced a strongly upregulatedion of pro-inflammatory genes and signaling pathways, HDL and cyclodextrin clearly enhanced LPS-induced signaling, especially of Interferon Regulatory Factor (IRF)1 and Nuclear Factor-κB (NF-κB)-p65 dependent genes
Overall design: Total RNA obtained from bone marrow derived macrophages incubated for 24h with 300ug/ml HDL or 4h with 4% cyclodextrin, compared to PBS treated control cells.
| Accession | PRJNA287756; GEO: GSE70155 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | van der Vorst EPC et al., "High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.", Cell Metab, 2017 Jan 10;25(1):197-207 |
| Submission | Registration date: 23-Jun-2015
Maastricht University |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 543372 |
| Data volume, Processed Mbytes | 16 |
| Data volume, Supplementary Mbytes | 29 |