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Organizing biological data
Goal: Here, we use Single Molecule Real-Time (SMRT) sequencing to sequence PCR-amplified, cloned SCA10 expansion to elucidate their repeat motif structure.
Conclusions: The three expansions that are examined in this study all have interruption motifs of varying sequencing and composition throughout the expansion allele. We expect these results to alter our understanding of desease symptoms and the underlying pathology of SCA10. Less...
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