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Organizing biological data
In this context the aim is to determine histone modification marks that are associated with restricted cell fate of neuronal progenitors in the developing cerebral cortex of the mouse. We detected expression changes between rostral (motor) and caudal (visual) cortex for H3K4 trimethylation (H3K4me3), a modification linked to transcriptional activation. Therefore, we performed ChIP-Seq with regard to H3K4me3 patterns.
Understanding these signatures is one step in achieving a comprehensive view on the epigenetic impact on cortical development and in identifying new therapeutic targets or strategies.
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