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2 additional projects are components of the MCPyV ST activates Max target genes by recruiting TRRAP/EP400 complex.
To determine if EP400 knockdown would affect Max target genes in Merkel cell carcinoma cell line MKL-1, we performed RNA-seq analyses of MKL-1 cells inducibly expressing EP400 shRNA and compared to ChIP-seq data using BETA analyses.
Overall design: EP400 was inducibly reduced with shRNA in MKL-1 cells to analyze gene regulation.
| Accession | PRJNA287017; GEO: GSE69876 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Cheng J et al., "Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.", PLoS Pathog, 2017 Oct;13(10):e1006668 |
| Submission | Registration date: 15-Jun-2015
James A. DeCaprio, Medical Oncology, Dana-Farber Cancer Institute |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 6 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 6 |
| GEO DataSets | 1 |