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Accession: PRJNA285838 ID: 285838

Homo sapiens (human)

Transcriptome analysis of CD4+ T cells reveals imprint of BACH2 and IFNγ regulation

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We used RNA sequencing to profile over 70 transcriptomes of CD4+ T cells, a cell type crucial for Coeliac Disease CD pathogenesis, in both stimulated and resting samples from individuals with CD and unaffected controls The data gave us the opportunity to (i) compare gene expression between cases and controls; (ii) specifically assess whether genes that have been genetically associated with the disease were being DE; (iii) and also look for known and novel aspects of pathogenesis in the transcriptome of this specific cellular compartment. More...
AccessionPRJNA285838; GEO: GSE69549
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsQuinn EM et al., "Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation.", PLoS One, 2015;10(10):e0140049
SubmissionRegistration date: 4-Jun-2015
Genomic Research, Clinical Medicine, Trinity College Dublin
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments74
Publications
PubMed1
PMC1
Other datasets
BioSample74
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes7
SRA Data Details
ParameterValue
Data volume, Gbases189
Data volume, Tbytes0.13

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