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Genome Information for Homo sapiens
Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a major cause of hepatocellular carcinoma (HCC).
More...Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a major cause of hepatocellular carcinoma (HCC). Despite this link, there is a paucity of information regarding the genetic alterations of HCC arising from NASH. Through whole-genome sequencing of three NASH-associated HCC and matched germline lymphocyte, and subsequent targeted sequencing in additional affected individuals, we discovered for the first time common mutations of CTNNB1 (36.4%), TP53 (15.2%) and PNLIP (12.1%) in this malignancy.
Less...| Accession | PRJEB3964 |
| Scope | Monoisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Submission | Registration date: 28-May-2015
CUHK |
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