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2 additional projects are components of the Methyl-CpG-binding domain (MBD) sequencing of neuroblastoma tumors.
The DNA methylome of 42 primary neuroblastoma tumors is profiled by enrichment with a methyl-CpG-binding domain (MBD) and massively parallel sequencing
Overall design: DNA of 42 primary tumors is sheared (fragments of ± 200 bp), followed by MBD-based (MethylCap kit of Diagenode) enrichement, library preparation and multiplexing. Captured DNA fractions were sequenced paired-end on Illumina Genome Analyzer IIx.
| Accession | PRJNA284948; GEO: GSE69224 |
| Data Type | Epigenomics |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | - Decock A et al., "Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma.", Oncotarget, 2016 Jan 12;7(2):1960-72
- Decock A et al., "DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing.", Sci Data, 2016 Feb 2;3:160004
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| Submission | Registration date: 26-May-2015
Center for Medical Genetics, Ghent University |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 42 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 42 |
| GEO DataSets | 1 |