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Accession: PRJNA284490 ID: 284490

Homo sapiens (human)

Comparison of the gene expression profiles of carfilzomib-resistant derivatives versus parental human myeloma cell lines

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KMS-11 and KMS-34 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. More...
AccessionPRJNA284490; GEO: GSE69078
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsRiz I et al., "KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.", Oncotarget, 2015 Jun 20;6(17):14814-31
SubmissionRegistration date: 20-May-2015
Anatomy and Regenerative Biology, George Washington University
RelevanceMedical
Project Data:
Resource NameNumber
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PubMed1
PMC1
Other datasets
GEO DataSets2
GEO Data Details
ParameterValue
Data volume, Spots655356
Data volume, Processed Mbytes14
Data volume, Supplementary Mbytes60

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