See
Genome Information for Homo sapiens
Bendamustine is a commonly-used drug to treat CLL patients. Because drug-responses among the patients are heterogeneous, we wanted to find candidate genes to predict sensitivity to the compound
We used microarrays to find genes whose expression correlates with the in vitro induced-cytotoxcity by a 24-hour incubation with bendamustine 25 µm
Overall design: RNA was extracted from CD19+ tumoral cells from 38 PBMCs of CLL cases
| Accession | PRJNA283970; GEO: GSE68163 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Montraveta A et al., "CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia.", Oncotarget, 2016 Feb 2;7(5):5507-20 |
| Submission | Registration date: 22-Apr-2015
IDIBAPS-HOSPITAL CLINIC |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 1876668 |
| Data volume, Processed Mbytes | 41 |
| Data volume, Supplementary Mbytes | 84 |