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1 additional project is a component of the Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression.
T-ALL cell line CUTLL1 was assessed for microRNA expression. Cells were treated with DMSO (ctr) or DAPT (10uM) to inhibit Notch1 cleavage for 3d and then harvested.
Overall design: 3 biological replicates were used per group (DMSO, n=3; DAPT, n=3).
| Accession | PRJNA283205; GEO: GSE68612 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Junker F et al., "Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.", Blood, 2015 Aug 20;126(8):993-1004 |
| Submission | Registration date: 6-May-2015
Freddy RADTKE, ISREC, Ecole polytechnique fédérale de Lausanne |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 5760 |
| Data volume, Processed Mbytes | 1 |
| Data volume, Supplementary Mbytes | 6 |