This SuperSeries is composed of the SubSeries listed below.
Overall design: Refer to individual Series
| Accession | PRJNA282585; GEO: GSE68387 |
| Type | Umbrella project |
| Publications (total 3) Less... | - Römer M et al., "ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis.", PLoS One, 2016;11(2):e0149263
More...- Römer M et al., "ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis.", PLoS One, 2016;11(2):e0149263
- Luisier R et al., "Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.", Toxicol Sci, 2014 Jun;139(2):501-11
- Lempiäinen H et al., "Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice.", PLoS One, 2011 Mar 24;6(3):e18216
Less... |
| Submission | Registration date: 29-Apr-2015
Novartis |
| Relevance | Superseries |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 6 |
| PMC | 4 |
| Other datasets |
| GEO DataSets | 19 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 58197593 |
| Data volume, Processed Mbytes | 1307 |
| Data volume, Supplementary Mbytes | 5739 |
IMI MARCAR Project: towards novel biomarkers for cancer risk assessment encompasses the following 18 sub-projects:
| Project Type | Number of Projects |
| Transcriptome or Gene expression | 18 |
BioProject
accession | Organism | Title |
|---|
| PRJNA282924 | Homo sapiens | Transcriptional profiling of Primary Human Hepatocytes (PHH) depleted for PXR and treated with CITCO or Phenobarbital in -/+EGF medium (Novartis) | | PRJNA282919 | Homo sapiens | Transcriptional profiling of Primary Human Hepatocytes (PHH) depleted for CAR and treated with CITCO or Phenobarbital in -/+EGF medium (Novartis) | | PRJNA191782 | Mus musculus | Expression data from CD-1 mouse liver samples obtained from in-vivo treatment with genotoxic carcinogens, non-genotoxic carcinogens or non-hepatocarcinogens. (Novartis) | | PRJNA282515 | Mus musculus | Transcriptional profiling of C57BL-mice with humanized CAR/PXR or CAR/PXR-knockout treated with DCB and CPA (Novartis) | | PRJNA282516 | Mus musculus | Transcriptional profiling of mouse liver after short-term in vivo exposure (up to 56 days) of C57BL-mice to carcinogenic and non-carcinogenic chemicals (Novartis) |
List all 18 'Transcriptome or Gene expression' projects...BioProject
accession | Organism | Title |
|---|
| PRJNA282924 | Homo sapiens | Transcriptional profiling of Primary Human Hepatocytes (PHH) depleted for PXR and treated with CITCO or Phenobarbital in -/+EGF medium (Novartis) | | PRJNA282919 | Homo sapiens | Transcriptional profiling of Primary Human Hepatocytes (PHH) depleted for CAR and treated with CITCO or Phenobarbital in -/+EGF medium (Novartis) | | PRJNA191782 | Mus musculus | Expression data from CD-1 mouse liver samples obtained from in-vivo treatment with genotoxic carcinogens, non-genotoxic carcinogens or non-hepatocarcinogens. (Novartis) | | PRJNA282515 | Mus musculus | Transcriptional profiling of C57BL-mice with humanized CAR/PXR or CAR/PXR-knockout treated with DCB and CPA (Novartis) | | PRJNA282516 | Mus musculus | Transcriptional profiling of mouse liver after short-term in vivo exposure (up to 56 days) of C57BL-mice to carcinogenic and non-carcinogenic chemicals (Novartis) | | PRJNA282512 | Mus musculus | Transcriptional profiling of CD1 mouse liver after 28 days and 90 days of daily administration of Phenobarbital in vivo (Novartis) | | PRJNA281876 | Mus musculus | Trancriptomic profiling of hepatocytes and mesenchymal cells of mice treated with phenobarbital for 2 weeks (Novartis) | | PRJNA281268 | Mus musculus | Transcriptional profiling of microRNAs after short-term exposure of CD1-mice to carcinogenic and non-carcinogenic chemicals (Novartis) | | PRJNA283853 | Mus musculus | Transcriptomic profiling of liver of Ctnnb1-KO and WT mice after 12 weeks exposure to Phenobarbital (miRNA) (Novartis) | | PRJNA283858 | Mus musculus | Transcriptomic profiling of liver of Ctnnb1-KO and WT mice after 12 weeks exposure to Phenobarbital (mRNA) (Novartis) | | PRJNA284239 | Mus musculus | Transcriptomic profiling of C57BL/APC-KO mice after 9 months treatment with Phenobarbital (Novartis) | | PRJNA317638 | Mus musculus | Time series trancriptional profiling of mouse liver after up to 13 weeks administration of Phenobarbital [mRNA] (Novartis) | | PRJNA281880 | Rattus norvegicus | Chronic subacute (incl. one subchronic study) exposure of Wistar rats to (non-)carcinogenic compound (Novartis) | | PRJNA281874 | Rattus norvegicus | Trancriptomic profiling of liver tumors in rats after chronical phenobarbital treatment (Novartis) | | PRJNA281875 | Rattus norvegicus | Trancriptomic profiling of hepatocytes and mesenchymal cells of rats treated with nongenotoxic carcinogens for up to 2 weeks (Novartis) | | PRJNA281878 | Rattus norvegicus | Trancriptional profiling of rat liver after short-term (up tp 14 days) administration of carcinogenic and non-carcinogenic chemicals (Dept. Cognitive Systems,...) | | PRJNA283201 | Rattus norvegicus | Trancriptional profiling of rat bladder after daily administration of Pioglitazone and Rosiglitazone in vivo (miRNA) (Novartis) | | PRJNA283202 | Rattus norvegicus | Trancriptional profiling of rat bladder after daily administration of Pioglitazone and Rosiglitazone in vivo (mRNA) (Novartis) |
Less... |