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Accession: PRJNA282515 ID: 282515

Mus musculus (house mouse)

Transcriptional profiling of C57BL-mice with humanized CAR/PXR or CAR/PXR-knockout treated with DCB and CPA

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This project is a component of the IMI MARCAR Project: towards novel biomarkers for cancer risk assessment
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17 additional projects are components of the IMI MARCAR Project: towards novel biomarkers for cancer risk assessment.
47588 additional projects are related by organism.
To investigate the role of the nuclear receptors CAR (constitutive androstane receptor) and PXR (Pregnane X receptor) in mediating the effects of non-genotoxic carcinogens, groups of mice humanised or deleted for CAR and PXR were treated with 1,4-Dichlorobenzene or cyproterone acetate for 3d and liver tissue harvested for expression profiling. More...
AccessionPRJNA282515; GEO: GSE68365
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
SubmissionRegistration date: 28-Apr-2015
Novartis
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots1351110
Data volume, Processed Mbytes31
Data volume, Supplementary Mbytes109

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