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Accession: PRJNA279797 ID: 279797

Homo sapiens (human)

FoxO1 inhibition by apelin/APJ signaling in endothelial cells

See Genome Information for Homo sapiens
Evaluation of gene transcripts that are downstream of apelin/APJ and FoxO1 signaling in HUVECs Overall design: Duplicates per group, subjected to: 1) control siRNA, 2) apelin and APJ siRNA, and 3) FoxO1 siRNA
AccessionPRJNA279797; GEO: GSE67390
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsHwangbo C et al., "Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects.", Sci Transl Med, 2017 Sep 13;9(407)
Grants
  • "Role of Apelin in the Systemic and Pulmonary Vasculature" (Grant ID K08 HL095654, National Heart, Lung, and Blood Institute)
  • "Role of the Apelin-APJ Pathway in Human Atherosclerosis" (Grant ID L30 HL097940, National Heart, Lung, and Blood Institute)
  • "Role of MicroRNAs 424 and 503 in Pulmonary Arterial Hypertension" (Grant ID R01 HL113005, National Heart, Lung, and Blood Institute)
  • "Endothelium in Health and Disease: Pursuit of Novel Mechanisms to Promote Vascular Homeostasis" (Grant ID AHA_14EIA17890000, American Heart Association-American Stroke Association)
SubmissionRegistration date: 29-Mar-2015
Internal Medicine, Yale University
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots283926
Data volume, Processed Mbytes8
Data volume, Supplementary Mbytes2

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