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Accession: PRJNA279588 ID: 279588

Mus musculus (house mouse)

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

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47588 additional projects are related by organism.
We report that Dnmt1 is crucial during perinatal intestinal development. Loss of Dnmt1 in intervillus progenitor cells causes global hypomethylation, DNA damage, premature differentiation, and apoptosis, and consequently, loss of nascent villi. More...
AccessionPRJNA279588; GEO: GSE67363
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsElliott EN et al., "Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.", Development, 2015 Jun 15;142(12):2163-72
SubmissionRegistration date: 27-Mar-2015
Klaus Kaestner Lab, Genetics, University of Pennsylvania Perelman School of Medicine
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments5
Publications
PubMed1
PMC1
Other datasets
BioSample5
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes1
SRA Data Details
ParameterValue
Data volume, Gbases18
Data volume, Mbytes11512

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