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Accession: PRJNA279168 ID: 279168

Homo sapiens (human)

NPM‐ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development

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We present evidence to support a new model of Anaplastic Large Cell Lymphoma (ALCL) pathogenesis in which the malignancy is initiated in early thymocytes, prior to TCR rearrangement which is bypassed in NPM‐ALK transgenic mice following Notch1 expression. More...
AccessionPRJNA279168; GEO: GSE67131
Data TypeVariation
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsMalcolm TI et al., "Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.", Nat Commun, 2016 Jan 12;7:10087
SubmissionRegistration date: 20-Mar-2015
Technological Advances for Genomics and Clinics (TAGC), INSERM
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots7777840
Data volume, Processed Mbytes153
Data volume, Supplementary Mbytes794

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