Gastrointestinal symptoms of those with irritable bowel syndrome (IBS) may be related to food intolerance to a group of carbohydrates known as fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP).
More...Gastrointestinal symptoms of those with irritable bowel syndrome (IBS) may be related to food intolerance to a group of carbohydrates known as fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP). FODMAP malaborption and subsequent fermentation by the gut microbiome is believed to be a mechanism of action. We undertook a double-blind randomized cross-over trial to determine the efficacy of a low FODMAP diet in children with IBS. To address the potential role of the microbiome we examined the gut (stool) microbiome of children with IBS at baseline (prior to any intervention) of Responders (>50% decrease in abdominal pain frequency specific to the low FODMAP diet) vs. Non-responders (no robust response to any dietary intervention). Per Linear Discriminant Analysis Effect Size analysis Responders were enriched in OTUs with high saccharolytic capacity.
Less...| Accession | PRJNA279111 |
| Data Type | Targeted Locus (Loci) |
| Scope | Environment |
| Organism | human gut metagenome[Taxonomy ID: 408170] unclassified sequences; metagenomes; organismal metagenomes; human gut metagenome |
| Submission | Registration date: 23-Mar-2015
Baylor College of Medicine |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| BioSample | 33 |
No public data is linked to this project. Any recently released data that cites this project will be linked to it within a few days.