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Accession: PRJNA224736 ID: 224736

Mus musculus (house mouse)

RNA-seq transcriptome profiling of motor neurons (MNs) and surrounding white matter glia (WM) microdissected from pre-symptomatic mouse model of spinal muscular atrophy (SMA)

See Genome Information for Mus musculus
We report tramscriptome perturbations in MNs and WM of SMA mouse, prior to first morphological and biochemical synaptic defects Overall design: Examination of ventral horn MNs and WM isolated from lumbar segment spinal cords from wild type (WT) and SMA mice
AccessionPRJNA224736; GEO: GSE51735
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsZhang Z et al., "Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy.", Proc Natl Acad Sci U S A, 2013 Nov 26;110(48):19348-53
SubmissionRegistration date: 25-Oct-2013
Gideon Dreyfuss, Biochemistry and Biophysics, University of Pennsylvania School of Medicine
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments8
Publications
PubMed1
PMC1
Other datasets
BioSample8
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes2
SRA Data Details
ParameterValue
Data volume, Gbases242
Data volume, Tbytes0.15

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