In this study we use Tag-sequencing in eye-antennal and wing imaginal discs across Drosophila species to determine a set of conserved eye-specific developmental genes. Next, we perform motif discovery analysis using the tool i-cisTarget, to depict the core gene developmental network underlying compound eye photoreceptor. The Glass position weight matrix appears as the most highly overrepresented motif, thus positioning Glass as a master regulator in compound eye photoreceptor development. Differential gene expression analysis by RNA-seq in D.melanogaster wild-type eye-antennal versus glass mutant [gl 60j] shows that the majority of our predicted Glass targets show strong downregulation in the glass mutant.
This SuperSeries is composed of the SubSeries listed below.
Overall design: Refer to individual Series.
| Accession | PRJNA171883; GEO: GSE39784 |
| Type | Umbrella project |
| Publications | Naval-Sánchez M et al., "Comparative motif discovery combined with comparative transcriptomics yields accurate targetome and enhancer predictions.", Genome Res, 2013 Jan;23(1):74-88 |
| Submission | Registration date: 31-Jul-2012
Laboratory of Computational Biology, Center for Human Genetics, KULeuven |
| Relevance | Superseries |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 11 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 10 |
| GEO DataSets | 3 |
This project encompasses the following 2 sub-projects:
| Project Type | Number of Projects |
| Transcriptome or Gene expression | 2 |
BioProject
accession | Name | Title |
|---|
| PRJNA171885 | Drosophila melanogaster | RNA-seq in wild-type and glass mutant eye-antennal discs in Drosophila melanogaster (Laboratory of Computational...) | | PRJNA171886 | Tag-seq profiling in eye-antennal and wing imaginal discs of D. melanogaster, D. yakuba and D. virilis | Tag-seq profiling in eye-antennal and wing imaginal discs of D. melanogaster, D. yakuba and D. virilis (Laboratory of Computational...) |
|