See
Genome Information for Streptomyces collinus
Streptomyces collinus Tü 365 is the producer of the antibiotic kirromycin. Kirromycin targets bacterial translation elongation factor Tu (EF-Tu) a currently underexplored target for anti-microbial therapy. The complete genome was determined to study kirromycin production in cellular context.
| Accession | PRJNA171216 |
| Data Type | Genome sequencing |
| Scope | Monoisolate |
| Organism | Streptomyces collinus Tu 365[Taxonomy ID: 1214242] Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces collinus; Streptomyces collinus Tu 365 |
| Publications (total 5) Less... | - Rückert C et al., "Complete genome sequence of the kirromycin producer Streptomyces collinus Tü 365 consisting of a linear chromosome and two linear plasmids.", J Biotechnol, 2013 Dec;168(4):739-40
More...- Rückert C et al., "Complete genome sequence of the kirromycin producer Streptomyces collinus Tü 365 consisting of a linear chromosome and two linear plasmids.", J Biotechnol, 2013 Dec;168(4):739-40
- Musiol EM et al., "Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS.", Chem Biol, 2011 Apr 22;18(4):438-44
- Laiple KJ et al., "The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-alpha-decarboxylase, KirD, which is involved in the biosynthesis of the precursor beta-alanine.", J Antibiot (Tokyo), 2009 Aug;62(8):465-8
- Weber T et al., "Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety.", Chem Biol, 2008 Feb;15(2):175-88
- Wolf H et al., "Kirromycin, an inhibitor of the 30 S ribosomal subunits function.", FEBS Lett, 1972 Apr 1;21(3):347-350
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| Grants | - "GenoMik-Plus" (Grant ID 0313805, Federal Ministry for Education and Research)
- "GenoMik-Transfer: GenBioCom" (Grant ID 0315585, Federal Ministry for Education and Research)
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| Submission | Registration date: 6-Aug-2013
Bielefeld University |
| Relevance | Industrial |
| Locus Tag Prefix | B446 |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| Nucleotide (Genomic DNA) | 3 |
| Protein Sequences | 7115 |
| Publications |
| PubMed | 5 |
| Other datasets |
| BioSample | 1 |
| Assembly | 1 |