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Accession: PRJNA169161 ID: 169161

Rattus norvegicus (Norway rat)

A novel 3-D organotypic culture model by co-culturing alpha-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix

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The increased α-smooth muscle-actin positive cancer-associated fibroblastic cells (CAF) in the desmoplastic stroma may relate to a more aggressive cancer and worse survival outcomes for intrahepatic cholangiocarcinoma (ICC) patients We developed a novel 3-D organotypic culture model by co-culturing α-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix. More...
AccessionPRJNA169161; GEO: GSE38889
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismRattus norvegicus[Taxonomy ID: 10116]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus
Publications
  • Manzanares MÁ et al., "Transforming Growth Factors α and β Are Essential for Modeling Cholangiocarcinoma Desmoplasia and Progression in a Three-Dimensional Organotypic Culture Model.", Am J Pathol, 2017 May;187(5):1068-1092
  • Campbell DJ et al., "Novel organotypic culture model of cholangiocarcinoma progression.", Hepatol Res, 2012 Nov;42(11):1119-30
SubmissionRegistration date: 23-Jun-2012
Pathology, Virginia Commonwealth University
RelevanceModel Organism
Project Data:
Resource NameNumber
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Publications
PubMed2
PMC2
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots404287
Data volume, Processed Mbytes9
Data volume, Supplementary Mbytes55

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