Homo sapiens (ID 168) - BioProject

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Accession: PRJNA168 ID: 168

Homo sapiens (human)

RefSeq annotation of the human reference genome assembly

See Genome Information for Homo sapiens

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66643 additional projects are related by organism.

The reference sequence (RefSeq) genome assembly is provided by NCBI using assembly instructions provided by the International Human Genome Project. More...

Accession	PRJNA168
Data Type	RefSeq Genome
Scope	Monoisolate
Organism	Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Publications (total 3429) Less...	Mohajeri K et al., "Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.", Genome Res, 2016 Nov;26(11):1453-1467 More... Mohajeri K et al., "Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.", Genome Res, 2016 Nov;26(11):1453-1467 Antonacci F et al., "Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability.", Nat Genet, 2014 Dec;46(12):1293-302 Genovese G et al., "Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes.", Am J Hum Genet, 2013 Sep 5;93(3):411-21 Mueller JL et al., "Independent specialization of the human and mouse X chromosomes for the male germ line.", Nat Genet, 2013 Sep;45(9):1083-7 Floutsakou I et al., "The shared genomic architecture of human nucleolar organizer regions.", Genome Res, 2013 Dec;23(12):2003-12 Watson CT et al., "Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.", Am J Hum Genet, 2013 Apr 4;92(4):530-46 Genovese G et al., "Using population admixture to help complete maps of the human genome.", Nat Genet, 2013 Apr;45(4):406-14, 414e1-2 Falconer E et al., "DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.", Nat Methods, 2012 Nov;9(11):1107-12 Itsara A et al., "Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing.", Am J Hum Genet, 2012 Apr 6;90(4):599-613 Lemmers RJ et al., "A unifying genetic model for facioscapulohumeral muscular dystrophy.", Science, 2010 Sep 24;329(5999):1650-3 Antonacci F et al., "A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk.", Nat Genet, 2010 Sep;42(9):745-50 Lemmers RJ et al., "Worldwide population analysis of the 4q and 10q subtelomeres identifies only four discrete interchromosomal sequence transfers in human evolution.", Am J Hum Genet, 2010 Mar 12;86(3):364-77 Teague B et al., "High-resolution human genome structure by single-molecule analysis.", Proc Natl Acad Sci U S A, 2010 Jun 15;107(24):10848-53 Pyo CW et al., "Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.", PLoS One, 2010 Dec 29;5(12):e15115 Hu L et al., "Profiling of endogenous serum phosphorylated peptides by titanium (IV) immobilized mesoporous silica particles enrichment and MALDI-TOFMS detection.", Anal Chem, 2009 Jan 1;81(1):94-104 Garber M et al., "Closing gaps in the human genome using sequencing by synthesis.", Genome Biol, 2009;10(6):R60 Scholz CJ et al., "Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum.", Protein Pept Lett, 2009;16(10):1244-8 Neafsey P et al., "Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.", J Toxicol Environ Health B Crit Rev, 2009;12(5-6):334-61 Matic I et al., "Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.", J Proteome Res, 2008 Sep;7(9):4050-7 Xue Y et al., "Adaptive evolution of UGT2B17 copy-number variation.", Am J Hum Genet, 2008 Sep;83(3):337-46 Zody MC et al., "Evolutionary toggling of the MAPT 17q21.31 inversion region.", Nat Genet, 2008 Sep;40(9):1076-83 Horton R et al., "Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.", Immunogenetics, 2008 Jan;60(1):1-18 Knipscheer P et al., "Ubc9 sumoylation regulates SUMO target discrimination.", Mol Cell, 2008 Aug 8;31(3):371-82 Young JM et al., "Extensive copy-number variation of the human olfactory receptor gene family.", Am J Hum Genet, 2008 Aug;83(2):228-42 Cole CG et al., "Finishing the finished human chromosome 22 sequence.", Genome Biol, 2008;9(5):R78 Faure C et al., "Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.", J Cell Sci, 2007 Sep 1;120(Pt 17):3034-44 Lemmers RJ et al., "Specific sequence variations within the 4q35 region are associated with facioscapulohumeral muscular dystrophy.", Am J Hum Genet, 2007 Nov;81(5):884-94 Matsuoka S et al., "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.", Science, 2007 May 25;316(5828):1160-6 Wang B et al., "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.", Science, 2007 May 25;316(5828):1194-8 Schindler EM et al., "The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes.", J Invest Dermatol, 2007 May;127(5):1094-106 Takeda K et al., "Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.", J Biol Chem, 2007 Mar 9;282(10):7522-31 Luo W et al., "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.", EMBO J, 2007 Mar 21;26(6):1511-21 Li W et al., "A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.", Nature, 2007 Mar 15;446(7133):333-7 Godeny MD et al., "The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.", Cell Signal, 2007 Mar;19(3):600-9 Wissing J et al., "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.", Mol Cell Proteomics, 2007 Mar;6(3):537-47 Sakita-Suto S et al., "Aurora-B regulates RNA methyltransferase NSUN2.", Mol Biol Cell, 2007 Mar;18(3):1107-17 Flores-Delgado G et al., "A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.", J Proteome Res, 2007 Mar;6(3):1165-75 Su Q et al., "Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.", EMBO Rep, 2007 Mar;8(3):265-70 Gwack Y et al., "Biochemical and functional characterization of Orai proteins.", J Biol Chem, 2007 Jun 1;282(22):16232-43 Liu B et al., "Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.", Cell, 2007 Jun 1;129(5):903-14 Trojer P et al., "L3MBTL1, a histone-methylation-dependent chromatin lock.", Cell, 2007 Jun 1;129(5):915-28 Sablina AA et al., "The tumor suppressor PP2A Abeta regulates the RalA GTPase.", Cell, 2007 Jun 1;129(5):969-82 Sugiyama N et al., "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.", Mol Cell Proteomics, 2007 Jun;6(6):1103-9 Sims AE et al., "FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.", Nat Struct Mol Biol, 2007 Jun;14(6):564-7 Berkovich E et al., "Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.", Nat Cell Biol, 2007 Jun;9(6):683-90 Boutet SC et al., "Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.", Cell, 2007 Jul 27;130(2):349-62 Yu Y et al., "Determination of the sites of tyrosine O-sulfation in peptides and proteins.", Nat Methods, 2007 Jul;4(7):583-8 Grimmler M et al., "Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.", Cell, 2007 Jan 26;128(2):269-80 Chu I et al., "p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.", Cell, 2007 Jan 26;128(2):281-94 Sun P et al., "PRAK is essential for ras-induced senescence and tumor suppression.", Cell, 2007 Jan 26;128(2):295-308 Smith CA et al., "aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.", EMBO J, 2007 Jan 24;26(2):468-80 Li HH et al., "A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.", EMBO J, 2007 Jan 24;26(2):402-11 Abida WM et al., "FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.", J Biol Chem, 2007 Jan 19;282(3):1797-804 Bignone PA et al., "Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.", J Biol Chem, 2007 Jan 12;282(2):888-96 Xu Y et al., "Modeling of a human circadian mutation yields insights into clock regulation by PER2.", Cell, 2007 Jan 12;128(1):59-70 Feig C et al., "Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.", EMBO J, 2007 Jan 10;26(1):221-31 Chakrabandhu K et al., "Palmitoylation is required for efficient Fas cell death signaling.", EMBO J, 2007 Jan 10;26(1):209-20 Wisniewski JR et al., "Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue.", Mol Cell Proteomics, 2007 Jan;6(1):72-87 Nakano-Kobayashi A et al., "Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.", EMBO J, 2007 Feb 21;26(4):1105-16 Yao Z et al., "Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.", EMBO J, 2007 Feb 21;26(4):1068-80 Stork B et al., "Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.", EMBO J, 2007 Feb 21;26(4):1140-9 Park CS et al., "Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells.", Eur J Cell Biol, 2007 Feb;86(2):111-23 Rikova K et al., "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.", Cell, 2007 Dec 14;131(6):1190-203 Shambharkar PB et al., "Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.", EMBO J, 2007 Apr 4;26(7):1794-805 Cuadrado A et al., "A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.", EMBO J, 2007 Apr 18;26(8):2115-26 Cho H et al., "Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.", FEBS Lett, 2007 Apr 17;581(8):1542-8 Cukier IH et al., "Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.", FEBS Lett, 2007 Apr 17;581(8):1661-72 Jiang Y et al., "Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.", Leuk Res, 2007 Apr;31(4):541-5 Tu LC et al., "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.", Mol Cell Proteomics, 2007 Apr;6(4):575-88 Alvarez M et al., "DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.", Mol Biol Cell, 2007 Apr;18(4):1167-78 Maegawa M et al., "Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers.", Mol Cancer Res, 2007 Apr;5(4):393-401 Makoff AJ et al., "Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.", Genome Biol, 2007;8(6):R114 Bousquet C et al., "Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway.", EMBO J, 2006 Sep 6;25(17):3943-54 Aikawa Y et al., "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.", EMBO J, 2006 Sep 6;25(17):3955-65 Konishi H et al., "CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.", J Biol Chem, 2006 Sep 29;281(39):28919-31 Lee MF et al., "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.", Biochem Biophys Res Commun, 2006 Sep 29;348(3):826-31 Gory-Fauré S et al., "STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.", J Biol Chem, 2006 Sep 22;281(38):28387-96 Gao C et al., "CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s.", FEBS Lett, 2006 Sep 18;580(21):5096-104 Pellegrini M et al., "Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.", Nature, 2006 Sep 14;443(7108):222-5 Prakriya M et al., "Orai1 is an essential pore subunit of the CRAC channel.", Nature, 2006 Sep 14;443(7108):230-3 Karbowniczek M et al., "Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.", J Biol Chem, 2006 Sep 1;281(35):25447-56 Wu SL et al., "Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).", Mol Cell Proteomics, 2006 Sep;5(9):1610-27 Scott GK et al., "A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.", EMBO J, 2006 Oct 4;25(19):4423-35 Salcedo A et al., "Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.", EMBO J, 2006 Oct 18;25(20):4752-62 To KK et al., "The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression.", EMBO J, 2006 Oct 18;25(20):4784-94 Vatinel S et al., "An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.", Biochim Biophys Acta, 2006 Oct;1763(10):1098-107 Huang J et al., "Repression of p53 activity by Smyd2-mediated methylation.", Nature, 2006 Nov 30;444(7119):629-32 Chini CC et al., "Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.", J Biol Chem, 2006 Nov 3;281(44):33276-82 Olsen JV et al., "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", Cell, 2006 Nov 3;127(3):635-48 Gilkes DM et al., "MDMX regulation of p53 response to ribosomal stress.", EMBO J, 2006 Nov 29;25(23):5614-25 Park S et al., "Regulation of RKIP binding to the N-region of the Raf-1 kinase.", FEBS Lett, 2006 Nov 27;580(27):6405-12 Le Cam L et al., "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.", Cell, 2006 Nov 17;127(4):775-88 Lyst MJ et al., "Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.", EMBO J, 2006 Nov 15;25(22):5317-28 Liu F et al., "PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.", FEBS Lett, 2006 Nov 13;580(26):6269-74 Lamalice L et al., "Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.", J Biol Chem, 2006 Nov 10;281(45):34009-20 Mostaqul Huq MD et al., "Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.", EMBO J, 2006 Nov 1;25(21):5094-104 Kossatz U et al., "C-terminal phosphorylation controls the stability and function of p27kip1.", EMBO J, 2006 Nov 1;25(21):5159-70 Greco TM et al., "Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells.", Proc Natl Acad Sci U S A, 2006 May 9;103(19):7420-5 Sakurai N et al., "Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin.", J Biol Chem, 2006 May 19;281(20):14288-95 Gregory SG et al., "The DNA sequence and biological annotation of human chromosome 1.", Nature, 2006 May 18;441(7091):315-21 Nouaille S et al., "Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.", EMBO Rep, 2006 May;7(5):512-8 Belouzard S et al., "Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.", EMBO J, 2006 Mar 8;25(5):932-42 Zody MC et al., "Analysis of the DNA sequence and duplication history of human chromosome 15.", Nature, 2006 Mar 30;440(7084):671-5 Taylor TD et al., "Human chromosome 11 DNA sequence and analysis including novel gene identification.", Nature, 2006 Mar 23;440(7083):497-500 Pastorino L et al., "The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.", Nature, 2006 Mar 23;440(7083):528-34 LeBron C et al., "Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.", EMBO J, 2006 Mar 22;25(6):1196-206 Jin Y et al., "14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.", EMBO J, 2006 Mar 22;25(6):1207-18 de Graaf K et al., "The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site.", BMC Biochem, 2006 Mar 2;7:7 Kim EA et al., "Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2.", J Biol Chem, 2006 Mar 17;281(11):7489-97 Maurer U et al., "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.", Mol Cell, 2006 Mar 17;21(6):749-60 Scherer SE et al., "The finished DNA sequence of human chromosome 12.", Nature, 2006 Mar 16;440(7082):346-51 Bakema JE et al., "Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.", J Immunol, 2006 Mar 15;176(6):3603-10 Wu X et al., "Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.", Cancer Res, 2006 Mar 15;66(6):2997-3005 Fritz A et al., "Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.", J Biol Chem, 2006 Mar 10;281(10):6236-45 Krick R et al., "CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein.", Biochem Biophys Res Commun, 2006 Mar 10;341(2):343-50 Guo H et al., "Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.", Biochem J, 2006 Mar 1;394(Pt 2):379-87 Watt MJ et al., "Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.", Am J Physiol Endocrinol Metab, 2006 Mar;290(3):E500-8 Komamura-Kohno Y et al., "Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.", FEBS J, 2006 Mar;273(6):1224-39 Radhakrishnan SK et al., "CDK9 phosphorylates p53 on serine residues 33, 315 and 392.", Cell Cycle, 2006 Mar;5(5):519-21 Gupte RS et al., "Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.", Cell Cycle, 2006 Mar;5(6):653-60 McBride KM et al., "Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation.", Proc Natl Acad Sci U S A, 2006 Jun 6;103(23):8798-803 Bose R et al., "Phosphoproteomic analysis of Her2/neu signaling and inhibition.", Proc Natl Acad Sci U S A, 2006 Jun 27;103(26):9773-8 Chen J et al., "Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.", FEBS Lett, 2006 Jun 26;580(15):3624-30 Shahbazian D et al., "The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.", EMBO J, 2006 Jun 21;25(12):2781-91 Mal AK "Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.", EMBO J, 2006 Jul 26;25(14):3323-34 Batthyany C et al., "Reversible post-translational modification of proteins by nitrated fatty acids in vivo.", J Biol Chem, 2006 Jul 21;281(29):20450-63 Webb DJ et al., "Identification of phosphorylation sites in GIT1.", J Cell Sci, 2006 Jul 15;119(Pt 14):2847-50 Martin KH et al., "Cortactin phosphorylation sites mapped by mass spectrometry.", J Cell Sci, 2006 Jul 15;119(Pt 14):2851-3 Shintani Y et al., "Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.", EMBO J, 2006 Jul 12;25(13):3045-55 Oliver AW et al., "Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.", EMBO J, 2006 Jul 12;25(13):3179-90 Pardo OE et al., "FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.", EMBO J, 2006 Jul 12;25(13):3078-88 Vitari AC et al., "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.", Biochem J, 2006 Jul 1;397(1):223-31 di Bari MG et al., "c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.", EMBO Rep, 2006 Jul;7(7):727-33 Wang SE et al., "HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.", Cancer Cell, 2006 Jul;10(1):25-38 Pei JJ et al., "P70 S6 kinase mediates tau phosphorylation and synthesis.", FEBS Lett, 2006 Jan 9;580(1):107-14 Gu YM et al., "Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.", FEBS Lett, 2006 Jan 9;580(1):305-10 Brummer T et al., "Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.", J Biol Chem, 2006 Jan 6;281(1):626-37 Matsuzono Y et al., "In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p.", J Biol Chem, 2006 Jan 6;281(1):36-42 Xie Y et al., "The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.", Oncogene, 2006 Jan 5;25(1):70-8 Su Q et al., "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.", Proc Natl Acad Sci U S A, 2006 Jan 3;103(1):63-8 Li Q et al., "Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.", J Biol Chem, 2006 Jan 20;281(3):1495-505 Zhang Z et al., "Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.", J Biol Chem, 2006 Jan 20;281(3):1746-54 Dodson GE et al., "DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.", J Biol Chem, 2006 Jan 20;281(3):1692-7 Marchini A et al., "Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.", J Mol Biol, 2006 Jan 20;355(3):590-603 Nusbaum C et al., "DNA sequence and analysis of human chromosome 8.", Nature, 2006 Jan 19;439(7074):331-5 Wang X et al., "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.", J Biol Chem, 2006 Jan 13;281(2):782-91 Lin YW et al., "Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.", J Biol Chem, 2006 Jan 13;281(2):915-26 Macdonald A et al., "Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.", BMC Cell Biol, 2006 Jan 10;7:1 D'Ambrosio C et al., "Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.", Mol Cell Proteomics, 2006 Jan;5(1):97-113 Chu F et al., "Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.", Mol Cell Proteomics, 2006 Jan;5(1):194-203 Tzatsos A et al., "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.", Mol Cell Biol, 2006 Jan;26(1):63-76 Evdokimova V et al., "Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.", Mol Cell Biol, 2006 Jan;26(1):277-92 Niiya F et al., "Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.", Oncogene, 2006 Feb 9;25(6):827-37 Chen C et al., "Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD.", FEBS Lett, 2006 Feb 6;580(3):813-21 Bernier M et al., "Binding of manumycin A inhibits IkappaB kinase beta activity.", J Biol Chem, 2006 Feb 3;281(5):2551-61 Arlander SJ et al., "Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.", J Biol Chem, 2006 Feb 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Functional regions and a structural model of the enzyme.", J Biol Chem, 1987 Mar 5;262(7):3086-91 Wong GG et al., "Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.", Science, 1987 Mar 20;235(4795):1504-8 Tate KM et al., "Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis.", Biochemistry, 1987 Jan 27;26(2):338-43 Do YS et al., "Characterization of pure human renal renin. Evidence for a subunit structure.", J Biol Chem, 1987 Jan 25;262(3):1037-43 Lockridge O et al., "Complete amino acid sequence of human serum cholinesterase.", J Biol Chem, 1987 Jan 15;262(2):549-57 Arai K et al., "Glycation and inactivation of human Cu-Zn-superoxide dismutase. 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Identification of phosphorylation sites and two major structural domains.", J Biol Chem, 1986 Oct 5;261(28):13333-41 Iberg N et al., "Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.", J Biol Chem, 1986 Oct 15;261(29):13542-5 Chung DW et al., "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.", Biochemistry, 1986 May 6;25(9):2410-7 Shackelford DA et al., "Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.", J Biol Chem, 1986 Jun 25;261(18):8334-41 Bock SC et al., "Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization.", Biochemistry, 1986 Jul 29;25(15):4292-301 Bar-Zvi D et al., "Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II.", J Biol Chem, 1986 Jul 25;261(21):9614-21 Fojo SS et al., "Human preproapolipoprotein C-II. Analysis of major plasma isoforms.", J Biol Chem, 1986 Jul 25;261(21):9591-4 Gould KL et al., "The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.", Mol Cell Biol, 1986 Jul;6(7):2738-44 Fesus L et al., "Transglutaminase-sensitive glutamine residues of human plasma fibronectin revealed by studying its proteolytic fragments.", Eur J Biochem, 1986 Jan 15;154(2):371-4 Borowski M et al., "Distribution of gamma-carboxyglutamic acid residues in partially carboxylated human prothrombins.", J Biol Chem, 1986 Feb 5;261(4):1624-8 Hortin G et al., "Identification of the site of sulfation of the fourth component of human complement.", J Biol Chem, 1986 Feb 5;261(4):1786-93 Chan PK et al., "Amino acid sequence of protein B23 phosphorylation site.", J Biol Chem, 1986 Feb 5;261(4):1868-72 Hortin G et al., "Identification of two sites of sulfation of human heparin cofactor II.", J Biol Chem, 1986 Dec 5;261(34):15827-30 Liguri G et al., "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.", Biochemistry, 1986 Dec 2;25(24):8089-94 Holt JC et al., "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.", Biochemistry, 1986 Apr 22;25(8):1988-96 Ishioka N et al., "Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.", Proc Natl Acad Sci U S A, 1986 Apr;83(8):2363-7 Prelli F et al., "The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.", J Biol Chem, 1985 Oct 25;260(24):12895-8 Koch N et al., "Ia-associated invariant chain is fatty acylated before addition of sialic acid.", Biochemistry, 1985 Oct 22;24(22):6185-90 Kishimoto A et al., "Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.", J Biol Chem, 1985 Oct 15;260(23):12492-9 Gould KL et al., "Protein kinase C phosphorylates pp60src at a novel site.", Cell, 1985 Oct;42(3):849-57 Davis RJ et al., "Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.", Proc Natl Acad Sci U S A, 1985 Jun;82(12):4080-4 Beckmann RJ et al., "The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs.", Nucleic Acids Res, 1985 Jul 25;13(14):5233-47 Foster DC et al., "The nucleotide sequence of the gene for human protein C.", Proc Natl Acad Sci U S A, 1985 Jul;82(14):4673-7 Schultz AM et al., "Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein.", Science, 1985 Jan 25;227(4685):427-9 Carrey EA et al., "Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.", EMBO J, 1985 Dec 30;4(13B):3735-42 Faust PL et al., "Cloning and sequence analysis of cDNA for human cathepsin D.", Proc Natl Acad Sci U S A, 1985 Aug;82(15):4910-4 Davis RJ et al., "Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.", Proc Natl Acad Sci U S A, 1985 Apr;82(7):1974-8 Babel W et al., "Structure of human-basement-membrane (type IV) collagen. Complete amino-acid sequence of a 914-residue-long pepsin fragment from the alpha 1(IV) chain.", Eur J Biochem, 1984 Sep 17;143(3):545-56 Vulliet PR et al., "Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.", J Biol Chem, 1984 Nov 25;259(22):13680-3 Guild BC et al., "HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure.", J Biol Chem, 1984 Nov 10;259(21):13504-10 Fairwell T et al., "Acetyl-blocked N-terminal structures of sorbitol and aldehyde dehydrogenases.", FEBS Lett, 1984 May 21;170(2):281-9 Seydewitz HH et al., "The location of a second in vivo phosphorylation site in the A alpha-chain of human fibrinogen.", Thromb Res, 1984 Mar 1;33(5):487-98 Murray KJ et al., "Amino acid sequence of the phosphorylation site of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.", J Biol Chem, 1984 Jun 25;259(12):7673-81 Rinderknecht E et al., "Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation.", J Biol Chem, 1984 Jun 10;259(11):6790-7 Strauch AR et al., "A vascular smooth muscle alpha-isoactin biosynthetic intermediate in BC3H1 cells. Identification of acetylcysteine at the NH2 terminus.", J Biol Chem, 1984 Jun 10;259(11):7224-9 Pohl G et al., "Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.", Biochemistry, 1984 Jul 31;23(16):3701-7 Guild BC et al., "Human and murine class I MHC antigens share conserved serine 335, the site of HLA phosphorylation in vivo.", J Biol Chem, 1984 Jul 25;259(14):9235-40 Takahashi N et al., "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.", Proc Natl Acad Sci U S A, 1984 Jan;81(2):390-4 Byrne RE et al., "The enzyme that cleaves apolipoprotein A-II upon in vitro incubation of human plasma high-density lipoprotein-3 with blood polymorphonuclear cells is an elastase.", J Biol Chem, 1984 Dec 10;259(23):14537-43 Frantíková V et al., "Amino acid sequence of the N-terminal region of human hemopexin.", FEBS Lett, 1984 Dec 10;178(2):213-6 Takahashi N et al., "Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues.", Proc Natl Acad Sci U S A, 1984 Apr;81(7):2021-5 Guild BC et al., "HLA-A2 and HLA-B7 antigens are phosphorylated in vitro by rous sarcoma virus kinase (pp60v-src) at a tyrosine residue encoded in a highly conserved exon of the intracellular domain.", Proc Natl Acad Sci U S A, 1983 May;80(10):2894-8 Powell JR et al., "Amino acid sequence analysis of the asparagine-288 region of the carbohydrate variants of human plasminogen.", Biochemistry, 1983 Feb 15;22(4):923-7 Castor CW et al., "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.", Proc Natl Acad Sci U S A, 1983 Feb;80(3):765-9 Keutmann HT et al., "Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation.", J Biol Chem, 1983 Dec 10;258(23):14521-6 Claesson L et al., "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.", Proc Natl Acad Sci U S A, 1983 Dec;80(24):7395-9 McKay MJ et al., "Action of human liver cathepsin B on the oxidized insulin B chain.", Biochem J, 1983 Aug 1;213(2):467-71 Drakenberg T et al., "beta-Hydroxyaspartic acid in vitamin K-dependent protein C.", Proc Natl Acad Sci U S A, 1983 Apr;80(7):1802-6 Kurono Y et al., "Kinetics of the rapid modification of human serum albumin with trinitrobenzenesulfonate and localization of its site.", J Pharm Sci, 1983 Apr;72(4):432-5 Hemmings BA et al., "Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.", Eur J Biochem, 1982 Oct;127(3):473-81 Ishaque A et al., "The complete amino acid sequence of the rabbit P2 protein.", J Biol Chem, 1982 Jan 25;257(2):592-5 Larhammar D et al., "Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.", Cell, 1982 Aug;30(1):153-61 Geahlen RL et al., "Phosphorylation of cAMP-dependent protein kinase subunits.", Adv Enzyme Regul, 1982;20:195-209 Shoji S et al., "Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.", Proc Natl Acad Sci U S A, 1981 Feb;78(2):848-51 Björk I et al., "The site in human antithrombin for functional proteolytic cleavage by human thrombin.", FEBS Lett, 1981 Apr 20;126(2):257-60 Kärgel HJ et al., "Action of rat liver cathepsin L on glucagon.", Acta Biol Med Ger, 1981;40(9):1139-43 Rylatt DB et al., "Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.", Eur J Biochem, 1980 Jun;107(2):529-37 Shapiro R et al., "Sites of nonenzymatic glycosylation of human hemoglobin A.", J Biol Chem, 1980 Apr 10;255(7):3120-7 Hayes ML et al., "Carbohydrate of the human plasminogen variants. III. Structure of the O-glycosidically linked oligosaccharide unit.", J Biol Chem, 1979 Sep 25;254(18):8777-80 Shoji S et al., "Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase.", J Biol Chem, 1979 Jul 25;254(14):6211-4 Orr HT et al., "Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies.", Biochemistry, 1979 Dec 11;18(25):5711-20 Smith CG et al., "Effect of delta 9-tetrahydrocannabinol (THC) on female reproductive function.", Adv Biosci, 1978 Jul 22-23;22-23:449-67 Mak A et al., "Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle.", Proc Natl Acad Sci U S A, 1978 Aug;75(8):3588-92 Parham P et al., "Carbohydrate moiety of HLA antigens. Antigenic properties and amino acid sequences around the site of glycosylation.", J Biol Chem, 1977 Nov 10;252(21):7555-67 Schlesinger DH et al., "Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva.", J Biol Chem, 1977 Mar 10;252(5):1689-95 Heaney-Kieras J et al., "Limited pepsin digestion of human plasma albumin.", J Biol Chem, 1977 Jun 25;252(12):4326-9 Sairam MR et al., "Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.", Can J Biochem, 1977 Jul;55(7):755-60 Kingston IB et al., "Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.", Proc Natl Acad Sci U S A, 1977 Dec;74(12):5377-81 Mole JE et al., "Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.", Biochemistry, 1977 Aug 9;16(16):3507-13 Flynn TJ et al., "Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.", J Biol Chem, 1977 Aug 25;252(16):5864-70 Lejin D "[Viscosimetry in clinical practice].", Med Pregl, 1977;30(9-10):477-82 Denys H et al., "Cystitis emphysematosa.", Acta Urol Belg, 1977;45(4):327-31 Koida M et al., "Post-proline cleaving enzyme. 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Acetylation status.", J Biol Chem, 1971 May 10;246(9):3001-7 Baldwin GS et al., "Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin.", Science, 1971 Feb 12;171(3971):579-81 Robbins KC et al., "The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin.", J Biol Chem, 1967 May 25;242(10):2333-42 Less...
Submission	Registration date: 27-Feb-2009 Genome Reference Consortium International Human Genome Sequencing Consortium (IHGSC)

Project Data:

Resource Name	Number of Links
Sequence data
Nucleotide (total)	82654
Genomic DNA	941
Transcript	81713
Protein Sequences	115338
Publications
PubMed	3429
PMC	844

Genome assemblies, organelles and plasmids:

Assembly GCF_000001405.39 :

Name	RefSeq	GenBank
Chromosome	NC_000001.11
Chromosome	NC_000001.11	CM000663.2
Mitochondrion	NC_012920.1	J01415.2
Chromosome	NC_000002.12	CM000664.2
Chromosome	NC_000002.12
Chromosome	NC_000003.12
Chromosome	NC_000003.12	CM000665.2
Chromosome	NC_000004.12	CM000666.2
Chromosome	NC_000004.12
Chromosome	NC_000005.10
Chromosome	NC_000005.10	CM000667.2
Chromosome	NC_000006.12	CM000668.2
Chromosome	NC_000006.12
Chromosome	NC_000007.14
Chromosome	NC_000007.14	CM000669.2
Chromosome	NC_000008.11	CM000670.2
Chromosome	NC_000008.11
Chromosome	NC_000009.12
Chromosome	NC_000009.12	CM000671.2
Chromosome	NC_000010.11	CM000672.2
Chromosome	NC_000010.11
Chromosome	NC_000011.10
Chromosome	NC_000011.10	CM000673.2
Chromosome	NC_000012.12	CM000674.2
Chromosome	NC_000012.12
Chromosome	NC_000013.11
Chromosome	NC_000013.11	CM000675.2
Chromosome	NC_000014.9	CM000676.2
Chromosome	NC_000014.9
Chromosome	NC_000015.10
Chromosome	NC_000015.10	CM000677.2
Chromosome	NC_000016.10	CM000678.2
Chromosome	NC_000016.10
Chromosome	NC_000017.11
Chromosome	NC_000017.11	CM000679.2
Chromosome	NC_000018.10	CM000680.2
Chromosome	NC_000018.10
Chromosome	NC_000019.10
Chromosome	NC_000019.10	CM000681.2
Chromosome	NC_000020.11	CM000682.2
Chromosome	NC_000020.11
Chromosome	NC_000021.9
Chromosome	NC_000021.9	CM000683.2
Chromosome	NC_000022.11	CM000684.2
Chromosome	NC_000022.11
Chromosome	NC_000023.11
Chromosome	NC_000023.11	CM000685.2
Chromosome	NC_000024.10	CM000686.2
Chromosome	NC_000024.10

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PRJNA31257 : The Human Genome Project, currently maintained by the Genome Reference Consortium (GRC)

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RefSeq annotation of the human reference genome assembly

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