See
Genome Information for Streptococcus pyogenes
This study examined the relationship between strain genotypes and patient phenotypes of the group A
Streptococcus serotype M3 organisms to help understand the underlying mechanisms of virulence. M3 strains have been studied extensively due to the fact that they cause a disproportionate number of invasive diseases including necrotizing fasciitis (flesh eating), bacteremia, and toxic shock and have a higher rate of lethal infections.
All sequences were compared to identify a set of SNPs that were found in the core metagenome (conserved in all strains and lacking foreign sequences such as prophage). Comparison of two clinical types, the carrier and invasive strains, demonstrated that allelic variation due to polymorphisms resulted in phenotypic differences although no uniformly present SNP was found that contributed to either phenotype. An expression microarray experiment has been published in GEO in GSE3966.
| Accession | PRJNA16752 |
| Type | Umbrella Comparative genomics project (Subtype:Comparative genomics) |
| Organism | Streptococcus pyogenes[Taxonomy ID: 1314] Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pyogenes |
| Publications | Beres SB et al., "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.", Proc Natl Acad Sci U S A, 2006 May 2;103(18):7059-64 |
| Submission | Registration date: 9-May-2006
Laboratory of Human Bacterial Pathogenesis |
| Related Resources | |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| Nucleotide (Genomic DNA) | 12 |
| SRA Experiments | 1 |
| Capillary Traces (Trace Archive) | 1 |
| Protein Sequences | 22360 |
| Publications |
| PubMed | 10 |
| PMC | 7 |
| Other datasets |
| BioSample | 13 |
| Assembly | 12 |
Streptococcus pyogenes encompasses the following 12 sub-projects:
| Project Type | Number of Projects |
| Genome sequencing |
12
|
|