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Accession: PRJNA165957 ID: 165957

NHLBI “Grand Opportunity” Exome Sequencing Project (GO-ESP)

NHLBI "Grand Opportunity” Exome Sequencing Project (GO-ESP), exome sequencing of well-phenotyped NHLBI cardiovascular and pulmonary disease cohort, clinical and family studies

The NHLBI “Grand Opportunity” Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the “exome”) that are associated with heart, lung and blood diseases. These and related diseases that are of high impact to public health and individuals from diverse racial and ethnic groups will be studied. These data may help researchers understand the causes of disease, contributing to better ways to prevent, diagnose, and treat diseases, as well as determine whether to tailor prevention and treatments to specific populations. This could lead to more effective treatments and reduce the likelihood of side effects.

GO-ESP is comprised of five collaborative components:

HeartGO: data and specimens from a consortium of six NHLBI population study cohorts -- ARIC (Atherosclerosis Risk in Communities), CARDIA (Coronary Artery Risk Development in Young Adults), CHS (Cardiovascular Health Study), FHS (Framingham Heart Study), JHS (Jackson Heart Study), and MESA (Multi-Ethnic Study of Atherosclerosis). More...

TypeUmbrella project (Subtype:Funding initiative)
SubmissionRegistration date: 15-May-2012
Related Resources
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments6994
Other datasets
Genotype and Phenotype (dbGaP)36
SRA Data Details
Data volume, Gbases71,669
Data volume, Tbytes31.75
NHLBI “Grand Opportunity” Exome Sequencing Project (GO-ESP) encompasses the following 27 sub-projects:
Project TypeNumber of Projects
Phenotype or Genotype26
PRJNA74801Homo sapiensNHLBI GO-ESP: Lung Cohorts Exome Sequencing Project (Cystic Fibrosis) (University of Washington)
PRJNA74813Homo sapiensNHLBI GO-ESP: Early-onset Myocardial Infarction (Broad EOMI) (MASSACHUSETTS INSTITUTE OF...)
PRJNA74855Homo sapiensNHLBI GO-ESP: Women's Health Initiative Exome Sequencing Project (WHI) (FRED HUTCHINSON CANCER RESEARCH...)
PRJNA74867Homo sapiensNHLBI GO-ESP: Lung Cohorts Exome Sequencing Project (Pulmonary Arterial Hypertension) (JOHNS HOPKINS UNIVERSITY)
PRJNA74821Homo sapiensNHLBI GO-ESP: Lung Cohorts Exome Sequencing Project (Lung Health Study of Chronic Obstructive Pulmonary Disease) (UNIVERSITY OF COLORADO DENVER)
List all 26 'Phenotype or Genotype' projects...
PRJNA192955Homo sapiensHomo sapiens Variation (NHLBI Grand Opportunity Exome...)

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