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Genome Information for Homo sapiens
To determine if treatment with a combined therapeutic regimen, which resulted in clinical benefit in a subset of patients in a clinical trial, alters miRNA expression in a way that may be used to guide treatment with these agents and to identify miRNAs that may be involved in the mechanism of action of this regimen
Overall design: Three-condition experiment, untreated tissue, post-temsirolimus alone treatment, post combination-treatment tissue. 33 total samples, including 5 samples resubmitted for quality control.
| Accession | PRJNA158407; GEO: GSE37131 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Wagenseller AG et al., "MicroRNAs induced in melanoma treated with combination targeted therapy of Temsirolimus and Bevacizumab.", J Transl Med, 2013 Sep 18;11:218 |
| Submission | Registration date: 10-Apr-2012
Craig Slingluff, Surgery, University of Virginia |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 49608 |
| Data volume, Processed Mbytes | 1 |
| Data volume, Supplementary Mbytes | 39 |