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Accession: PRJNA156321 ID: 156321

Homo sapiens (human)

MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2

See Genome Information for Homo sapiens
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This project is a component of the BT474 tumors, primary TN tumors and MCF10A-HER2/3 cells in the presence or absence of SHP2
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2 additional projects are components of the BT474 tumors, primary TN tumors and MCF10A-HER2/3 cells in the presence or absence of SHP2.
66644 additional projects are related by organism.
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. More...
AccessionPRJNA156321; GEO: GSE34524
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsAceto N et al., "Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.", Nat Med, 2012 Mar 4;18(4):529-37
SubmissionRegistration date: 20-Dec-2011
Functional Genomics, FMI
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots173214
Data volume, Processed Mbytes4
Data volume, Supplementary Mbytes22

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