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Accession: PRJNA155333 ID: 155333

Mus musculus (house mouse)

Systems analysis identifies an essential role for SHARPIN in macrophage TLR2 responses (Agilent)

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1 additional project is a component of the Systems analysis identifies an essential role for SHARPIN in macrophage TLR2 responses.
47588 additional projects are related by organism.
Our systems analysis reported here demonstrates that TLR-responses in macrophages are markedly impaired by SHARPIN deficiency, and that SHARPIN controls expression of a subset of TLR2-induced, NF-kB and AP-1 dependent genes that overlaps with those affected by the hypomorphic panr2 mutation in NEMO. More...
AccessionPRJNA155333; GEO: GSE29888
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsZak DE et al., "Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.", Proc Natl Acad Sci U S A, 2011 Jul 12;108(28):11536-41
SubmissionRegistration date: 31-Aug-2011
Aderem Lab, Seattle Biomedical Research Institute
RelevanceModel Organism
Project Data:
Resource NameNumber
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Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots1137248
Data volume, Processed Mbytes26
Data volume, Supplementary Mbytes372

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