BioProject

The Mouse Sequencing Consortium (MSC) was formed by the National Institutes of Health, the Wellcome Trust, and three private companies (GlaxoSmithKline, Merck Genome Research Institute and Affymetrix, Inc. More...

The Mouse Sequencing Consortium (MSC) was formed by the National Institutes of Health, the Wellcome Trust, and three private companies (GlaxoSmithKline, Merck Genome Research Institute and Affymetrix, Inc.) to accelerate efforts to sequence the mouse genome. Washington University, the Whitehead Institute for Biomedical Research (now the Broad Institute), and the The Sanger Institute were sequencing centers for this project. The initial MSC goal of 2.5 - 3x coverage of the mouse genome was met, and the results published. The group continued to sequence the genome with whole genome shotgun sequencing to at least 5X coverage.

The Genome Reference Consortium (GRC) was formed in 2008 to maintain the reference assembly for the human genome; it now also maintains the reference assembly for the mouse genome. The goals of the GRC are to correct regions that are misrepresented, to close remaining gaps, and to produce alternative assemblies of structurally variant loci. The consortium does experimental work to address gaps or sub-optimal sequence regions and has developed the infrastructure to review and curate assembly joins. The GRC consists of: The Wellcome Trust Sanger Institute, The Genome Center at Washington University, The European Bioinformatics Institute and The National Center for Biotechnology Information. The public can see regions under review and report genome problems at the GRC website, http://genomereference.org.