BioProject

The Wellcome Trust Sanger Institute began sequencing of the the 1.7 Gb zebrafish (Danio rerio) genome in 2001 using a combined approach of whole genome shotgun (WGS) sequencing with corresponding clone mapping and sequencing. More...

The Wellcome Trust Sanger Institute began sequencing of the the 1.7 Gb zebrafish (Danio rerio) genome in 2001 using a combined approach of whole genome shotgun (WGS) sequencing with corresponding clone mapping and sequencing. The previous WGS project, CABZ00000000, is assembly WGS31 and represents the whole genome assembled from Illumina and Sanger shotgun reads. The latest project replaces WGS with high quality finished clone sequence, closing remaining gaps and placing yet unlocalized sequence.

The Genome Reference Consortium (GRC) has taken over maintenance of the zebrafish assembly. The goals of this group are to correct regions that are misrepresented, to close remaining gaps, and to produce alternative assemblies of structurally variant loci. The consortium does experimental work to address gaps or sub-optimal sequence regions and has developed the infrastructure to review and curate assembly joins. The GRC consists of: The Wellcome Trust Sanger Institute, The Genome Center at Washington University, The European Bioinformatics Institute and The National Center for Biotechnology Information. The public can see regions under review and report genome problems at the GRC website, http://genomereference.org. Less...