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CURATION:
 Proteins: A standard nomenclature has been applied so that orthologs have the same name. Functional information may have been propagated from other adenovirus species.
 Protein-coding regions: The initiation codon for each CDS is assigned with as much confidence ... as possible. CDSs presumably inherited from the last common ancestor of all adenoviruses are indicated as genus-common, and all other CDSs as genus-specific. CDSs that have paralogues in one or more genomes are listed as members of named families. The evolutionary history of E3 and E4 is complex, frequently involving generation or loss of paralogues in whole or in part, accompanied by rapid sequence divergence. In E3, this is evident in a set of tandemly arranged CDSs encoding transmembrane proteins. All of these are listed as members of the MP family, regardless of whether sequence conservation is detectable.
 Transcripts: In mastadenoviruses, transcription arises from the early genes (E1A, E1B, E2A, E2B, E3 and E4), the intermediate genes (IX and IVa2) and the late genes (L, U and E2A-L). Certain transcriptional features are supported by experimental data for some of these genes in a few adenoviruses (particularly human adenovirus C). All transcriptional features not marked as experimentally supported are predictions made on the basis of conservation and relevance to CDS expression. The degree of confidence in each prediction depends on the feature under consideration. In primate adenoviruses, predictions for E3, E4 and the 5'-regions of E2A and E2B are generally the least certain. In non-primate mastadenoviruses, this trend is accentuated to the degree that predictions for introns in E3 and E4 are not provided, and those for the 5'-regions of E2A, E2B and IVa2 and for the intron separating the protein-coding exons of 33K are particularly tentative. In human adenovirus C, rightward-oriented transcripts from the late genes (L1-L5) are polyadenylated close downstream from polyadenylation signals at five locations (the 3'-ends of the pIIIa, pX, protease, control protein E3 12.5K and fiber CDSs), and those from the E3 genes (E3A and E3B) at two locations (the 3'-ends of the membrane protein E3 CR1-beta and control protein E3 14.7K CDSs). Only the polyadenylation signals for L3, E3B and L5 are conserved among all mastadenoviruses, whereas those for L1 and L2 are conserved in most mastadenoviruses and those for L4 and E3A in a few. In addition, potential additional polyadenylation signals exist at the 3'-ends of the penton base, pVII, V, pVI and fiber-2 CDSs in some mastadenoviruses, particularly those with non-primate hosts; the corresponding genes are listed as L1A, L1B, L1C, L2A and L5A, respectively. The gene corresponding to E3B is termed E3 in genomes lacking the E3A polyadenylation signal. In some instances where a TATA signal is not convincingly evident (particularly for E2A/E2B), a tentative assignment is made and marked as nominal.
ACCURACY: No potential sequence errors are noted.  more

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