In this issue

The Human
Genome Sequence

BLink Enhances
Entrez Exploration

Human Gene


Recent Publications

BLAST Additions


Mirror FTP Site
for GenBank




How can I determine what general class of protein I have from its sequence?


Aside from running a standard BLAST search‚ NCBI offers two ways to do this. You can perform a Conserved Domain Database Search using your protein sequence. From the Structure page (‚ select CDD.

You can also perform a search against the Clusters of Orthologous Groups (COGs)‚ a database containing 21 complete proteomes. From the COGs page (‚ select COGnitor.

How can I see all the LocusLink entries for human chromosome 22?
From the NCBI home page‚ select the human Map Viewer‚ then select chromosome 22. In the sidebar of the chromosome 22 map‚ click on the Chr.22 Resource link‚ which leads to a summary page with additional information about the chromosome. In the sidebar of the resource page‚ click on LocusLink Chr.22 Loci.

How can I see all the UniGene Clusters mapping to chromosome 22?

From the chromosome 22 resource page mentioned in the previous question‚ click on the UniGene Chr.22 Clusters link.

How can I set up a search using the PubMed “Cubby”so that I can retrieve only papers published since my last search?

You first need to register as a Cubby user. From PubMed‚ click on Cubby in the sidebar and follow the onscreen instructions.

To store a search‚ first run it as usual within PubMed‚ then click the Cubby link from the sidebar‚ and login to Cubby as prompted. Your current search will be displayed; press the Store in Cubby button to add it to your stored search list. To collect any new material‚ select the search of interest and press the What’s New for Selected button.

What classes of genetic variation are included in the dbSNP database?
The database accepts several classes of genetic variation‚ including SNPs‚ microsatellite repeats‚ and small insertion/deletion polymorphisms. The scope of dbSNP includes disease-causing clinical mutations as well as neutral polymorphisms.


NCBI News | Fall/Winter 2000