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UGID:916304     UniGene Hs.525557     Homo sapiens (human)   SERPINA1
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1)

Human protein-coding gene SERPINA1. Represented by 2501 ESTs from 248 cDNA libraries. Corresponds to 11 reference sequences (different isoforms). [UniGene 916304 - Hs.525557]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_522938.2 PREDICTED: alpha-1-antitrypsin isoform 5 P. troglodytes 100.0 417
NP_001121172.1 SERPINA1 gene product H. sapiens 100.0 417
NP_957026.1 rpl23 gene product D. rerio 87.6 104
XP_003945711.1 PREDICTED: alpha-1-antitrypsin 1-1 isoform 1 M. musculus 68.8 412
NP_001080271.1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 precursor X. laevis 59.3 393
Other hits (2 of 24) [Show all]SpeciesId(%)Len(aa)
XP_003902262.1 PREDICTED: alpha-1-antitrypsin isoform 1 P. anubis 95.2 417
XP_001099044.1 PREDICTED: alpha-1-antitrypsin isoform 4 M. mulatta 95.0 417

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: liver; mixed; lung; pancreas; connective tissue; uterus; uncharacterized tissue; mammary gland; intestine; spleen; blood; kidney; stomach; lymph node; heart; embryonic tissue; muscle; thyroid; eye; placenta; ovary; pharynx; testis; amniotic fluid; lymph; bone marrow; vascular; thymus; brain; cervix; prostate; trachea; ascites; bone; skin; adipose tissue; adrenal gland; mouth; epididymis
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 14
Map position: 14q32.1
UniSTS entry: Chr 14 G60004
UniSTS entry: Chr 14 RH1712
UniSTS entry: Chr 14 SGC32646 [Map Viewer]
UniSTS entry: Chr 14 SHGC-32639 [Map Viewer]
UniSTS entry: Chr 14 WIAF-2218
UniSTS entry: GDB:181554
UniSTS entry: Chr 14 RH1623
UniSTS entry: Chr 14 RH1620
UniSTS entry: Chr 14 D14S1217
UniSTS entry: Chr 14 hsa1attr
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (35)

BX161449.1 human full-length cDNA clone CS0DI028YP15 of Placenta of Homo sapiens (human) P
BX248257.1 human full-length cDNA clone CS0DM003YH14 of Fetal liver of Homo sapiens (human) P
BX248002.1 human full-length cDNA clone CS0DM003YH10 of Fetal liver of Homo sapiens (human) P
BX247968.1 human full-length cDNA clone CS0DE007YP21 of Placenta of Homo sapiens (human) P
NM_000295.4 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 1, mRNA PA
M26123.1 Human alpha-1-antitrypsin (alpha-1-AT) mRNA, 3' end
M11465.1 Human alpha-1-antitrypsin mRNA, complete cds P
K01396.1 Human alpha-1-antitrypsin mRNA, complete cds P
BC070163.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, mRNA (cDNA clone IMAGE:4733519) PA
NM_001002235.2 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 3, mRNA PA
NM_001002236.2 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 2, mRNA PA
BT019455.1 Homo sapiens serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 mRNA, complete cds P
AK026174.1 Homo sapiens cDNA: FLJ22521 fis, clone HRC12386, highly similar to AF113676 Homo sapiens clone FLB2803 PRO0684 mRNA PA
V00496.1 Human messenger RNA for alpha-1-antitrypsin (serine protease inhibitor)
DQ682455.1 Homo sapiens alpha-1 antitrypsin variant (AAT) mRNA, complete cds, alternatively spliced P
BC011991.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, mRNA (cDNA clone MGC:9222 IMAGE:3859644), complete cds PA
BC015642.2 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, mRNA (cDNA clone MGC:23330 IMAGE:4644658), complete cds PA
AK315637.1 Homo sapiens cDNA, FLJ96724, highly similar to Homo sapiens serine (or cysteine) proteinase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), mRNA P
X01683.1 Human mRNA for alpha 1-antitrypsin P
NM_001127707.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 11, mRNA PA
NM_001127706.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 10, mRNA PA
NM_001127705.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 9, mRNA PA
NM_001127704.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 8, mRNA PA
NM_001127703.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 7, mRNA PA
NM_001127702.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 6, mRNA PA
NM_001127701.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 5, mRNA PA
NM_001127700.1 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 4, mRNA PA
AF119873.1 Homo sapiens PRO2275 mRNA, complete cds PA
X17122.1 Human mRNA for alpha-1 antitrypsin variant P
X05826.1 Human macrophage alpha1-antitrypsin (alpha1-AT) mRNA 5'-end (L17)
X05827.1 Human macrophage alpha1-antitrypsin (alpha1-AT) mRNA 5'-end (L25)
X06096.1 Human macrophage alpha1-antitrypsin cap site region
FJ830375.1 Homo sapiens alpha-1-antitrypsin null variant (AAT) mRNA, partial cds
GU727620.1 Homo sapiens epididymis secretory sperm binding protein Li 44a mRNA, complete cds P
X02920.1 Human mRNA for alpha 1-antitrypsin carboxyterminal region (aa 268-394) P

EST sequences (10 of 2501) [Show all sequences]

AA961570.1 Clone IMAGE:1592625 kidney 3' read PA
AA962810.1 Clone IMAGE:1573715 kidney 3' read PA
AA970548.1 Clone IMAGE:1573880 kidney 3' read
AA970293.1 Clone IMAGE:1575229 kidney 3' read PA
AA976081.1 Clone IMAGE:1558433 lung 3' read PA
AA977573.1 Clone IMAGE:1561138 mixed 3' read PA
AA991218.1 Clone IMAGE:1606335 kidney 3' read A
AA995629.1 Clone IMAGE:1604194 lung 3' read PA
AI028288.1 Clone IMAGE:1644041 testis 3' read PA
R19197.1 Clone IMAGE:129937 mixed 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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