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UGID:300859     UniGene Mm.184752     Mus musculus (mouse)   Mthfd1l
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l)

Mouse protein-coding gene Mthfd1l. Represented by 303 ESTs from 117 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 300859 - Mm.184752]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_758512.3 Mthfd1l gene product M. musculus 100.0 976
NP_056255.2 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 2 precursor H. sapiens 94.7 977
NP_001229925.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial D. rerio 80.3 908
NP_001080574.1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase X. laevis 76.1 914
NP_509361.1 Protein K07E3.4, isoform a C. elegans 75.2 636
NP_564571.1 Formate--tetrahydrofolate ligase A. thaliana 72.5 627
XP_956550.1 C-1-tetrahydrofolate synthase N. crassa 65.9 915
NP_477254.1 pugilist, isoform A D. melanogaster 65.9 923
XP_001693688.1 10-formyltetrahydrofolate synthetase C. reinhardtii 64.5 590
NP_011720.3 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 S. cerevisiae 61.5 928
Other hits (2 of 56) [Show all]SpeciesId(%)Len(aa)
NP_001101932.2 Mthfd1l gene product R. norvegicus 97.5 976
XP_533450.2 PREDICTED: monofunctional C1-tetrahydrofolate synthase, mitochondrial C. lupus familiaris 94.8 901

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: embryonic tissue; brain; mixed; mammary gland; thymus; uncharacterized tissue; spleen; skin; liver; testis; pituitary gland; vagina; intestine; lung; bone marrow; pancreas; blood; kidney; eye; stomach; bone; extraembryonic tissue; prostate; connective tissue; ovary; salivary gland; heart; bladder; inner ear; uterus; nasopharynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10 A1|10
UniSTS entry: Chr 10 AI647056
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (28)

NM_172308.4 Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA P
AK038579.1 Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230045M11 product:weakly similar to C1-tetrahydrofolate synthase [Homo sapiens], full insert sequence P
AK075931.1 Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410004L15 product:weakly similar to C1-tetrahydrofolate synthase [Homo sapiens], full insert sequence P
U06665.1 Mus musculus Balb/c mid-G1 serum response (I-8-29) mRNA, 5' sequence P
BC049936.1 Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like, mRNA (cDNA clone IMAGE:5374413), partial cds PA
BC058265.1 Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like, mRNA (cDNA clone IMAGE:6489143), containing frame-shift errors PA
AK205129.1 Mus musculus cDNA, clone:Y1G0150L16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK204908.1 Mus musculus cDNA, clone:Y1G0150A06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search
AK203566.1 Mus musculus cDNA, clone:Y1G0145F10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search
AK202571.1 Mus musculus cDNA, clone:Y1G0142A10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search
AK200660.1 Mus musculus cDNA, clone:Y1G0135G12, strand:unspecified
AK199087.1 Mus musculus cDNA, clone:Y1G0130C04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search
AK197409.1 Mus musculus cDNA, clone:Y1G0125A12, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK192952.1 Mus musculus cDNA, clone:Y1G0110H20, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023882, based on BLAT search A
AK191963.1 Mus musculus cDNA, clone:Y1G0107H12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK187059.1 Mus musculus cDNA, clone:Y0G0139K24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK186628.1 Mus musculus cDNA, clone:Y0G0138B18, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK185610.1 Mus musculus cDNA, clone:Y0G0134K11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK182224.1 Mus musculus cDNA, clone:Y0G0121D24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK181871.1 Mus musculus cDNA, clone:Y0G0119N04, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK181751.1 Mus musculus cDNA, clone:Y0G0119F01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK181581.1 Mus musculus cDNA, clone:Y0G0118K24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000043735, based on BLAT search P
AK160025.1 Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420044H02 product:formyltetrahydrofolate synthetase domain containing 1, full insert sequence P
AK036284.1 Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630053M04 product:formyltetrahydrofolate synthetase domain containing 1, full insert sequence P
AK028211.1 Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810003M09 product:formyltetrahydrofolate synthetase domain containing 1, full insert sequence P
NM_001170786.1 Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA P
NM_001170785.1 Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA P
BC030437.1 Mus musculus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like, mRNA (cDNA clone MGC:40924 IMAGE:5374413), complete cds PA

EST sequences (10 of 303) [Show all sequences]

CA564477.1 Clone NIA:K0326F09_IMAGE:30056804 bone 5' read P
CA566119.1 Clone NIA:K0346D11_IMAGE:30058702 bone 5' read P
CA569271.1 Clone NIA:K0440B07_IMAGE:30062898 bone marrow 5' read P
CA577271.1 Clone NIA:K0707A12_IMAGE:30074219 bone marrow 5' read P
BY009899.1 Clone G730015O09 lung 5' read P
BY013180.1 Clone G730037C14 lung 5' read P
BY013823.1 Clone G730041L15 lung 5' read P
BY016625.1 Clone G830018A11 mammary gland 5' read P
BY022072.1 Clone G830050M10 mammary gland 5' read P
BY022092.1 Clone G830050N21 mammary gland 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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