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UGID:2138551     UniGene Hs.631657     Homo sapiens (human)   GNB3
Guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3)

Human protein-coding gene GNB3. Represented by 141 ESTs from 34 cDNA libraries. EST representation biased toward eye; retinoblastoma; adult. Corresponds to reference sequence NM_002075.2. [UniGene 2138551 - Hs.631657]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001110494.1 PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 3 M. mulatta 100.0 339
XP_003905931.1 PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1 P. anubis 100.0 339
NP_002066.1 GNB3 gene product H. sapiens 100.0 339
XP_003313511.1 PREDICTED: LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 P. troglodytes 99.7 339
NP_038558.1 Gnb3 gene product M. musculus 98.5 339
NP_001080452.1 guanine nucleotide binding protein (G protein), beta polypeptide 3 X. laevis 91.2 339
NP_997774.1 gnb1a gene product D. rerio 87.3 339
NP_496508.1 G Protein, Beta subunit family member (gpb-1) C. elegans 85.0 339
NP_525090.1 G protein beta-subunit 13F, isoform A D. melanogaster 82.7 339
XP_956704.2 guanine nucleotide-binding protein beta subunit N. crassa 74.9 351
NP_195172.1 guanine nucleotide-binding protein subunit beta A. thaliana 51.2 359
Other hits (2 of 55) [Show all]SpeciesId(%)Len(aa)
NP_001003004.1 GNB3 gene product C. lupus familiaris 98.2 339
XP_001497170.1 PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like E. caballus 98.2 339

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: eye [show more like this]
retinoblastoma [show more like this]
adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: eye; brain; uncharacterized tissue; mixed; lung; pineal gland; pituitary gland; muscle; placenta; connective tissue; pancreas; heart
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12p13
UniSTS entry: Chr 12 STS-H92898 [Map Viewer]
UniSTS entry: Chr 12 RH76209
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

BT009800.1 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 mRNA, complete cds P
NM_002075.2 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), mRNA P
M31328.1 Human guanine nucleotide-binding protein beta-3 subunit mRNA, complete cds P
AB209283.1 Homo sapiens mRNA for guanine nucleotide-binding protein, beta-3 subunit variant protein P
BC002454.2 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3, mRNA (cDNA clone MGC:1738 IMAGE:3342882), complete cds PA
BC000115.1 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3, mRNA (cDNA clone MGC:3116 IMAGE:3351520), complete cds PA
BC015920.1 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3, mRNA (cDNA clone MGC:20430 IMAGE:4648399), complete cds PA
AK313091.1 Homo sapiens cDNA, FLJ93574 P
AF501884.1 Homo sapiens guanine nucleotide binding protein beta 3 (GNB3) mRNA, complete cds P
U47930.1 Human G-protein beta-3 subunit mRNA, partial cds
AB593099.1 Homo sapiens GNB3 mRNA for guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, complete cds, clone: HP06683-RBb32F07 PA
AB593098.1 Homo sapiens GNB3 mRNA for guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, complete cds, clone: HP06683-RBb29B08 PA

EST sequences (10 of 141) [Show all sequences]

BX112979.1 Clone IMAGp998F12467_;_IMAGE:231947 pineal gland P
CB565934.1 Clone IMAGE:6519164 uncharacterized tissue 5' read P
CB565933.1 Clone IMAGE:6519165 uncharacterized tissue 5' read P
AI969125.1 Clone IMAGE:2545720 pituitary gland 3' read A
AW003591.1 Clone IMAGE:2545512 pituitary gland 3' read
AW026130.1 Clone IMAGE:2528980 brain 3' read
BX490995.1 Clone DKFZp686O1392 muscle 5' read
AW192884.1 Clone IMAGE:2678570 pancreas 3' read
BX953978.1 Clone DKFZp781J2351 uncharacterized tissue 5' read
AW949728.1 uncharacterized tissue A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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