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UGID:2063455     UniGene Hs.594444     Homo sapiens (human)   LMNA
Lamin A/C (LMNA)

Human protein-coding gene LMNA. Represented by 5206 ESTs from 548 cDNA libraries. EST representation biased toward neonate. Corresponds to 6 reference sequences (different isoforms). [UniGene 2063455 - Hs.594444]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001092024.1 LMNA gene product P. troglodytes 100.0 663
NP_733821.1 LMNA gene product H. sapiens 100.0 663
XP_001113604.2 PREDICTED: lamin-A/C M. mulatta 100.0 662
XP_003892858.1 PREDICTED: prelamin-A/C P. anubis 100.0 662
XP_864434.1 PREDICTED: prelamin-A/C isoform 4 C. lupus familiaris 99.5 664
NP_001002011.2 Lmna gene product M. musculus 99.0 664
NP_001095210.1 lamin-A X. laevis 82.4 664
NP_694503.1 lmna gene product D. rerio 75.7 658
Other hits (2 of 22) [Show all]SpeciesId(%)Len(aa)
NP_001029225.1 LMNA gene product B. taurus 99.5 571
XP_001499938.1 PREDICTED: prelamin-A/C isoform 1 E. caballus 99.2 662

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: neonate [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; skin; lung; connective tissue; uterus; placenta; uncharacterized tissue; testis; kidney; mouth; intestine; pancreas; mammary gland; vascular; liver; prostate; trachea; ovary; spleen; eye; heart; stomach; ascites; mixed; embryonic tissue; cervix; adrenal gland; bone; esophagus; blood; thymus; bladder; thyroid; salivary gland; bone marrow; adipose tissue; larynx; ganglia; muscle; lymph node; umbilical cord; nerve; pituitary gland; parathyroid; amniotic fluid; pharynx
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 1
Map position: 1q22
UniSTS entry: Chr 1 PMC169171P2
UniSTS entry: Chr 1 PMC169171P1
UniSTS entry: MARC_3281-3282:991936958:1
UniSTS entry: Chr 1 D20S1027 [Map Viewer]
UniSTS entry: Chr 1 RH69068
UniSTS entry: Chr 1 G15913
UniSTS entry: Chr 1 A004V35 [Map Viewer]
UniSTS entry: Chr 1 PMC169171P6
UniSTS entry: Chr 1 PMC169171P5
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (32)

M13452.1 Human lamin A mRNA, 3'end P
M13451.1 Human lamin C mRNA, complete cds P
AK130179.1 Homo sapiens cDNA FLJ26669 fis, clone MPG03096, highly similar to LAMIN A P
AK122732.1 Homo sapiens cDNA FLJ16247 fis, clone HCHON2003659, highly similar to LAMIN A P
NM_005572.3 Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA PA
AY357727.1 Homo sapiens progerin mRNA, complete cds PA
AY847597.1 Homo sapiens lamin A/C transcript variant 1 (LMNA) mRNA, complete cds, alternatively spliced P
AY847596.1 Homo sapiens lamin A/C transcript variant 1 (LMNA) mRNA, complete cds, alternatively spliced P
AY847595.1 Homo sapiens lamin A/C transcript variant 1 (LMNA) mRNA, complete cds, alternatively spliced P
AY528714.1 Homo sapiens rhabdomyosarcoma antigen MU-RMS-40.12 mRNA, complete cds, alternatively spliced P
AK026584.1 Homo sapiens cDNA: FLJ22931 fis, clone KAT07501, highly similar to HSLAMAR Human mRNA for nuclear envelope protein lamin A precursor PA
BC000511.2 Homo sapiens lamin A/C, mRNA (cDNA clone MGC:8539 IMAGE:2822703), complete cds PA
BC003162.1 Homo sapiens lamin A/C, mRNA (cDNA clone MGC:4219 IMAGE:2958052), complete cds PA
AF381029.1 Homo sapiens lamin Adel10 mRNA, partial cds, alternatively spliced P
AK057997.1 Homo sapiens cDNA FLJ25268 fis, clone STM05518, highly similar to LAMIN A P
AK056191.1 Homo sapiens cDNA FLJ31629 fis, clone NT2RI2003360, highly similar to LAMIN A P
AK056143.1 Homo sapiens cDNA FLJ31581 fis, clone NT2RI2002091, highly similar to LAMIN C P
AK309539.1 Homo sapiens cDNA, FLJ99580 P
BC033088.1 Homo sapiens lamin A/C, mRNA (cDNA clone MGC:45654 IMAGE:3623265), complete cds PA
AK098128.1 Homo sapiens cDNA FLJ40809 fis, clone TRACH2009661, highly similar to LAMIN A P
AK097801.1 Homo sapiens cDNA FLJ40482 fis, clone TESTI2043656, highly similar to LAMIN C P
AK294217.1 Homo sapiens cDNA FLJ55771 complete cds, highly similar to Lamin-A/C P
AK295390.1 Homo sapiens cDNA FLJ56081 complete cds, highly similar to Lamin-A/C P
BC018863.2 Homo sapiens lamin A/C, mRNA (cDNA clone IMAGE:3141665) PA
BC014507.1 Homo sapiens lamin A/C, mRNA (cDNA clone MGC:23638 IMAGE:4863480), complete cds PA
X03444.1 Human mRNA for nuclear envelope protein lamin A precursor P
X03445.1 Human mRNA for nuclear envelope protein lamin C precursor P
NM_001257374.1 Homo sapiens lamin A/C (LMNA), transcript variant 4, mRNA PA
NR_047544.1 Homo sapiens lamin A/C (LMNA), transcript variant 6, non-coding RNA PA
NR_047545.1 Homo sapiens lamin A/C (LMNA), transcript variant 5, non-coding RNA PA
NM_170708.3 Homo sapiens lamin A/C (LMNA), transcript variant 3, mRNA PA
NM_170707.3 Homo sapiens lamin A/C (LMNA), transcript variant 1, mRNA PA

EST sequences (10 of 5206) [Show all sequences]

AA954802.1 Clone IMAGE:1574293 kidney 3' read
AA961132.1 Clone IMAGE:1575511 intestine 3' read A
AA961563.1 Clone IMAGE:1592632 kidney 3' read P
AA968781.1 Clone IMAGE:1593672 kidney 3' read
R16152.1 Clone IMAGE:53164 brain 3' read A
AA971500.1 Clone IMAGE:1584376 lung 3' read
AA977289.1 Clone IMAGE:1589974 kidney 3' read
AA977422.1 Clone IMAGE:1590642 kidney 3' read
AA988072.1 Clone IMAGE:1603862 lung 3' read A
AA995633.1 Clone IMAGE:1604206 lung 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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