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UGID:911645     UniGene Hs.520898     Homo sapiens (human)   CTSB
Cathepsin B (CTSB)

Human protein-coding gene CTSB. Represented by 3315 ESTs from 709 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 911645 - Hs.520898]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003317964.1 PREDICTED: cathepsin B isoform 1 P. troglodytes 100.0 338
NP_680090.1 CTSB gene product H. sapiens 100.0 338
NP_031824.1 Ctsb gene product M. musculus 84.3 338
NP_001080410.1 uncharacterized protein LOC380102 precursor X. laevis 82.9 332
NP_998501.1 ctsba gene product D. rerio 78.8 329
NP_572920.1 cathepsin B1, isoform A D. melanogaster 66.7 339
NP_503383.1 Protein CPR-5 C. elegans 56.5 338
NP_563648.1 putative cathepsin B-like cysteine protease A. thaliana 54.2 312
Other hits (2 of 50) [Show all]SpeciesId(%)Len(aa)
XP_002805301.1 PREDICTED: cathepsin B-like M. mulatta 99.1 338
XP_003902454.1 PREDICTED: cathepsin B P. anubis 99.1 338

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; placenta; connective tissue; thyroid; uncharacterized tissue; skin; uterus; lung; liver; bone; intestine; blood; pancreas; eye; kidney; prostate; testis; ovary; mixed; mammary gland; embryonic tissue; stomach; spleen; vascular; mouth; bladder; adrenal gland; trachea; thymus; larynx; amniotic fluid; esophagus; ascites; parathyroid; heart; muscle; bone marrow; lymph node; cervix; ear; adipose tissue; salivary gland; pharynx; nerve; epididymis; pituitary gland; ganglia; umbilical cord; spinal cord; tonsil
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 8
Map position: 8p22
UniSTS entry: Chr 8 STS-M14221 [Map Viewer]
UniSTS entry: Chr 8 G54083
UniSTS entry: Chr 8 G61996
UniSTS entry: Chr 8 D8S2052
UniSTS entry: Chr 8 RH75619
UniSTS entry: Chr 8 RH11588
UniSTS entry: Chr 1 D10S275
UniSTS entry: Chr 8 CTSB_430
UniSTS entry: Chr 8 D8S1946 [Map Viewer]
UniSTS entry: Chr 1 GDB:434012
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (23)

BX647952.1 Homo sapiens mRNA; cDNA DKFZp686H1851 (from clone DKFZp686H1851) PA
BX647765.1 Homo sapiens mRNA; cDNA DKFZp686N0152 (from clone DKFZp686N0152) PA
AK130184.1 Homo sapiens cDNA FLJ26674 fis, clone MPG03491, highly similar to Cathepsin B precursor (EC 3.4.22.1) P
AK127308.1 Homo sapiens cDNA FLJ45376 fis, clone BRHIP3019880
NM_001908.3 Homo sapiens cathepsin B (CTSB), transcript variant 1, mRNA P
M13230.1 Human lysosomal proteinase cathepsin B mRNA, 3' end P
M14221.1 Human cathepsin B proteinase mRNA, complete cds P
BC095408.1 Homo sapiens cathepsin B, mRNA (cDNA clone MGC:110901 IMAGE:30334082), complete cds PA
BC010240.1 Homo sapiens cathepsin B, mRNA (cDNA clone MGC:17266 IMAGE:4154307), complete cds PA
L16510.1 Homo sapiens cathepsin B mRNA, complete cds P
AK290239.1 Homo sapiens cDNA FLJ78235 complete cds P
AK098296.1 Homo sapiens cDNA FLJ40977 fis, clone UTERU2014167
AK097384.1 Homo sapiens cDNA FLJ40065 fis, clone TESOP2000400, highly similar to CATHEPSIN B PRECURSOR (EC 3.4.22.1) P
AK092070.1 Homo sapiens cDNA FLJ34751 fis, clone NESOP2000231, highly similar to CATHEPSIN B PRECURSOR (EC 3.4.22.1) P
AK297687.1 Homo sapiens cDNA FLJ59133 complete cds, highly similar to Cathepsin B precursor (EC 3.4.22.1) P
AK296845.1 Homo sapiens cDNA FLJ58073 complete cds, moderately similar to Cathepsin B precursor (EC 3.4.22.1) P
AK075393.1 Homo sapiens cDNA PSEC0083 fis, clone NT2RP2005506, highly similar to CATHEPSIN B PRECURSOR (EC 3.4.22.1) P
NM_147783.2 Homo sapiens cathepsin B (CTSB), transcript variant 5, mRNA P
NM_147782.2 Homo sapiens cathepsin B (CTSB), transcript variant 4, mRNA P
NM_147781.2 Homo sapiens cathepsin B (CTSB), transcript variant 3, mRNA P
NM_147780.2 Homo sapiens cathepsin B (CTSB), transcript variant 2, mRNA P
Y18460.1 Homo sapiens mRNA for cathepsin B, partial P
L38712.1 Homo sapiens cathepsin B (CTSB) mRNA, alternatively spliced exons 2a and 2b

EST sequences (10 of 3315) [Show all sequences]

AA954664.1 Clone IMAGE:1554930 kidney 3' read A
AA836814.1 Clone IMAGE:1422643 kidney
AA865837.1 Clone IMAGE:1456858 kidney 3' read A
AA864248.1 Clone IMAGE:1460200 kidney 3' read
AA971303.1 Clone IMAGE:1574951 kidney 3' read
AA983730.1 Clone IMAGE:1490895 skin 3' read A
AA985222.1 Clone IMAGE:1629399 brain 3' read
AA988292.1 Clone IMAGE:1605519 kidney 3' read A
AA988372.1 Clone IMAGE:1593532 kidney 3' read
AI002467.1 Clone IMAGE:1592983 kidney 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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