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UGID:910795     UniGene Hs.520048     Homo sapiens (human)   HLA-DRA
Major histocompatibility complex, class II, DR alpha (HLA-DRA)

Human protein-coding gene HLA-DRA. Represented by 1829 ESTs from 340 cDNA libraries. Corresponds to reference sequence NM_019111.4. [UniGene 910795 - Hs.520048]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001127811.1 major histocompatibility complex, class II, DR alpha precursor P. troglodytes 100.0 253
NP_061984.2 HLA-DRA gene product H. sapiens 100.0 253
NP_034511.2 histocompatibility 2, class II antigen E alpha precursor M. musculus 80.8 254
NP_001091340.1 uncharacterized protein LOC100037177 precursor X. laevis 53.2 237
Other hits (2 of 14) [Show all]SpeciesId(%)Len(aa)
NP_001127770.1 MAMU-DRA gene product M. mulatta 98.4 253
XP_003897459.1 PREDICTED: mamu class II histocompatibility antigen, DR alpha chain-like P. anubis 97.6 253

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; uterus; lymph node; pharynx; uncharacterized tissue; mixed; pancreas; lymph; brain; skin; connective tissue; tonsil; blood; stomach; testis; intestine; adrenal gland; epididymis; larynx; ovary; spleen; thymus; placenta; bone marrow; kidney; thyroid; liver; eye; trachea; vascular; muscle; mouth; bladder; mammary gland; ascites; prostate; bone; heart; parathyroid; nerve; adipose tissue; esophagus; pineal gland; ganglia
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p21.3
UniSTS entry: Chr 6 PMC166015P1
UniSTS entry: Chr 6 RH78783 [Map Viewer]
UniSTS entry: Chr 6 PMC204479P1
UniSTS entry: Chr 5 A006J23
UniSTS entry: Chr 5 SHGC-132052
UniSTS entry: MARC_26692-26693:1034099311:3
UniSTS entry: Chr 6 RH1515 [Map Viewer]
UniSTS entry: Chr 5 G20870
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

J00194.1 human hla-dr antigen alpha-chain mrna & ivs fragments P
CR457013.1 Homo sapiens full open reading frame cDNA clone RZPDo834G105D for gene HLA-DRA, major histocompatibility complex, class II, DR alpha; complete cds, incl. stopcodon P
BC071659.1 Homo sapiens major histocompatibility complex, class II, DR alpha, mRNA (cDNA clone MGC:87851 IMAGE:5162925), complete cds PA
NM_019111.4 Homo sapiens major histocompatibility complex, class II, DR alpha (HLA-DRA), mRNA PA
M60334.1 Human MHC class II HLA-DR-alpha mRNA, complete cds P
K01171.1 Human HLA-DR alpha-chain mRNA P
M60333.1 Human MHC class II HLA-DRA mRNA, complete cds P
AK313123.1 Homo sapiens cDNA, FLJ93608, Homo sapiens major histocompatibility complex, class II, DR alpha(HLA-DRA), mRNA P
AK310161.1 Homo sapiens cDNA, FLJ17203 A
BC032350.1 Homo sapiens major histocompatibility complex, class II, DR alpha, mRNA (cDNA clone MGC:40279 IMAGE:5214156), complete cds PA
AK301354.1 Homo sapiens cDNA FLJ51117 complete cds, highly similar to HLA class II histocompatibility antigen, DRalpha chain precursor PA
AK301134.1 Homo sapiens cDNA FLJ51113 complete cds, highly similar to HLA class II histocompatibility antigen, DRalpha chain precursor PA
AK304429.1 Homo sapiens cDNA FLJ52115 complete cds, highly similar to HLA class II histocompatibility antigen, DRalpha chain precursor PA
AK297032.1 Homo sapiens cDNA FLJ57318 complete cds, highly similar to HLA class II histocompatibility antigen, DRalpha chain precursor PA
J00197.1 human hla-dr alpha-chain mrna for the leader and nh2-term
M35979.1 Human MHC class II HLA-DR-alpha chain mRNA, 5' end
J00195.1 human hla-dr alpha-chain mrna; partial
V00523.1 Human mRNA for histocompatibility antigen HLA-DR (fragment). The alpha chain P
V00528.1 Human mRNA fragment coding for histocompatibility antigen HLA-DR

EST sequences (10 of 1829) [Show all sequences]

AA961848.1 Clone IMAGE:1600329 uncharacterized tissue 3' read A
AA970345.1 Clone IMAGE:1576372 intestine 3' read
AA974229.1 Clone IMAGE:1585907 uncharacterized tissue 3' read A
AA974257.1 Clone IMAGE:1586298 uncharacterized tissue 3' read A
AA975244.1 Clone IMAGE:1588433 uncharacterized tissue 3' read A
AA996306.1 Clone IMAGE:1605824 kidney 3' read
AA902751.1 Clone IMAGE:1519124 uncharacterized tissue 3' read A
AI023617.1 Clone IMAGE:1643623 testis 3' read A
AI034011.1 Clone IMAGE:1646710 parathyroid 3' read
AI061391.1 Clone IMAGE:1728709 prostate 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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