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UGID:233900     UniGene Hs.438863     Homo sapiens (human)   NR1H3
Nuclear receptor subfamily 1, group H, member 3 (NR1H3)

Human protein-coding gene NR1H3. Represented by 316 ESTs from 138 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 233900 - Hs.438863]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_003951917.1 PREDICTED: oxysterols receptor LXR-alpha P. troglodytes 100.0 452
NP_001238863.1 NR1H3 gene product H. sapiens 100.0 452
NP_038867.2 Nr1h3 gene product M. musculus 96.4 444
NP_001017545.1 nr1h3 gene product D. rerio 82.9 368
NP_001086083.1 nuclear receptor subfamily 1, group H, member 2 X. laevis 80.3 389
Other hits (2 of 30) [Show all]SpeciesId(%)Len(aa)
XP_001109209.1 PREDICTED: oxysterols receptor LXR-alpha isoform 13 M. mulatta 99.1 446
XP_003909994.1 PREDICTED: oxysterols receptor LXR-alpha isoform 4 P. anubis 98.9 452

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: uncharacterized tissue; mixed; brain; lung; ovary; adipose tissue; uterus; vascular; cervix; prostate; kidney; placenta; intestine; embryonic tissue; mammary gland; liver; connective tissue; blood; testis; spleen; thyroid; heart; lymph node; muscle; thymus; parathyroid; bladder; tonsil; stomach; ascites; eye; salivary gland; bone; pancreas; trachea; adrenal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11p11.2
UniSTS entry: Chr 11 STS-U22662
UniSTS entry: Chr 11 PMC99927P1
UniSTS entry: Chr 11 STS-U22662
UniSTS entry: Chr 11 RH79033
UniSTS entry: Chr 11 PMC33205P3
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (17)

AK122661.1 Homo sapiens cDNA FLJ16096 fis, clone SPLEN2006232, highly similar to OXYSTEROLS RECEPTOR LXR-ALPHA P
NM_005693.3 Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, mRNA P
BT019411.1 Homo sapiens nuclear receptor subfamily 1, group H, member 3 mRNA, complete cds P
BC008819.2 Homo sapiens nuclear receptor subfamily 1, group H, member 3, mRNA (cDNA clone MGC:10474 IMAGE:3957848), complete cds PA
U22662.1 Human nuclear orphan receptor LXR-alpha mRNA, complete cds P
AK290614.1 Homo sapiens cDNA FLJ78537 complete cds P
AK309027.1 Homo sapiens cDNA, FLJ99068 P
AK311590.1 Homo sapiens cDNA, FLJ18632 P
AK313311.1 Homo sapiens cDNA, FLJ93824, highly similar to Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), mRNA P
NM_001130102.2 Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 3, mRNA P
NM_001130101.2 Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 2, mRNA P
AK302132.1 Homo sapiens cDNA FLJ56172 complete cds, highly similar to Oxysterols receptor LXR-alpha P
AB307698.1 Homo sapiens NR1H3 mRNA for liver X receptor alpha, complete cds P
HQ692819.1 Homo sapiens liver X nuclear receptor alpha variant 1 (NR1H3) mRNA, complete cds P
NM_001251934.1 Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 4, mRNA P
NM_001251935.1 Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 5, mRNA P
BC041172.1 Homo sapiens nuclear receptor subfamily 1, group H, member 3, mRNA (cDNA clone MGC:48988 IMAGE:5744574), complete cds PA

EST sequences (10 of 316) [Show all sequences]

AA991550.1 Clone IMAGE:1609694 mammary gland 3' read A
AI016420.1 Clone IMAGE:1622356 embryonic tissue 3' read PA
AI049684.1 Clone IMAGE:1700450 kidney 3' read PA
AI097478.1 Clone IMAGE:1707355 heart 3' read
AI150912.1 Clone IMAGE:1703393 brain 3' read P
BX100834.1 Clone IMAGp998C245803_;_IMAGE:2338895 lung
BX090032.1 Clone IMAGp998E20724_;_IMAGE:320251 parathyroid P
AI192005.1 Clone IMAGE:1738319 testis 3' read
AI206938.1 Clone IMAGE:1942883 uncharacterized tissue 3' read A
AI208561.1 Clone IMAGE:1837529 testis 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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