NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Help
Query Tips
Build Info
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
EST
SRA

NIH cDNA Projects
Finding cDNAs

UGID:162646     UniGene Hs.202179     Homo sapiens (human)   SMN2
Survival of motor neuron 2, centromeric (SMN2)

Human protein-coding gene SMN2. Represented by 301 ESTs from 158 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 162646 - Hs.202179]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001156488.1 PREDICTED: survival motor neuron protein isoform 7 P. troglodytes 100.0 296
NP_059107.1 SMN2 gene product H. sapiens 100.0 293
NP_035550.1 Smn1 gene product M. musculus 87.8 287
NP_001082386.1 survival of motor neuron 2, centromeric X. laevis 61.9 268
NP_571266.1 smn1 gene product D. rerio 59.3 270
Other hits (2 of 20) [Show all]SpeciesId(%)Len(aa)
XP_001096348.2 PREDICTED: survival motor neuron protein isoform 1 M. mulatta 98.6 293
XP_003919619.1 PREDICTED: LOW QUALITY PROTEIN: survival motor neuron protein P. anubis 97.0 298

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; embryonic tissue; cervix; liver; blood; placenta; intestine; prostate; mammary gland; vascular; uncharacterized tissue; muscle; kidney; stomach; skin; lung; mixed; pituitary gland; testis; amniotic fluid; uterus; eye; pancreas; heart; bone; pharynx; mouth; thyroid; lymph node; ear; ovary; adrenal gland; thymus; bladder; larynx; tonsil; salivary gland; connective tissue; ascites; nerve; ganglia
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 5
Map position: 5q13.2
UniSTS entry: Chr 5 D5S1946
UniSTS entry: Chr 5 SMN1
UniSTS entry: Chr 5 G20836
UniSTS entry: Chr 5 A006I11
UniSTS entry: Chr 5 D5S2463 [Map Viewer]
UniSTS entry: Chr 5 STS-U18423
UniSTS entry: Chr 5 D5S2798
UniSTS entry: Chr 5 D5S2797
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

BC070242.1 Homo sapiens survival of motor neuron 2, centromeric, mRNA (cDNA clone MGC:88227 IMAGE:4673318), complete cds PA
DQ185039.1 Homo sapiens survival of motor neuron 2 variant 1 (SMN2) mRNA, 3' UTR
NM_017411.3 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant d, mRNA PA
BC000908.2 Homo sapiens survival of motor neuron 2, centromeric, mRNA (cDNA clone MGC:5208 IMAGE:2985046), complete cds PA
NM_022875.2 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant a, mRNA PA
NM_022876.2 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant b, mRNA PA
NM_022877.2 Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant c, mRNA PA
U21914.1 Homo sapiens putative open reading frame; duplicate of the functional spinal muscular atrophy gene, cDNA clone BCD514, GenBank Accession Number U18423; it is not known if this copy of the gene is actually translated mRNA, partial cds PA
BC015308.1 Homo sapiens survival of motor neuron 2, centromeric, mRNA (cDNA clone MGC:20996 IMAGE:4427000), complete cds PA
AK289669.1 Homo sapiens cDNA FLJ76644 complete cds, highly similar to Homo sapiens survival of motor neuron 2, centromeric (SMN2), transcript variant a, mRNA P
JQ690866.1 Homo sapiens survival motor neuron protein isoform g (SMN2) mRNA, exons 2b, 4, 6 through 8 and partial cds, alternatively spliced P
JQ690864.1 Homo sapiens survival motor neuron protein isoform j (SMN2) mRNA, exons 2b, 3, 5, 6, 8 and partial cds, alternatively spliced P
JQ690862.1 Homo sapiens survival motor neuron protein isoform h (SMN2) mRNA, exons 2b, 4 through 6, 8 and partial cds, alternatively spliced P
JQ690865.1 Homo sapiens survival motor neuron protein isoform c (SMN2) mRNA, exons 2b through 4, 6, 8 and partial cds, alternatively spliced P
JQ690863.1 Homo sapiens survival motor neuron protein isoform i (SMN2) mRNA, exons 2b, 4, 6, 8 and partial cds, alternatively spliced P
JQ690861.1 Homo sapiens survival motor neuron protein isoform e (SMN2) mRNA, exons 2b, 4 through 8 and partial cds, alternatively spliced P

EST sequences (10 of 301) [Show all sequences]

AA954966.1 Clone IMAGE:1577759 mixed 3' read A
AA988429.1 Clone IMAGE:1601880 lung 3' read A
AA989486.1 Clone IMAGE:1606262 kidney 3' read A
AA927924.1 Clone IMAGE:1541852 mixed 3' read
AI075751.1 Clone IMAGE:1676884 embryonic tissue 3' read A
CB051613.1 Clone IMAGE:3289914 uncharacterized tissue 3' read A
R33396.1 Clone IMAGE:136170 placenta 5' read P
R33397.1 Clone IMAGE:136170 placenta 3' read A
AI224909.1 Clone IMAGE:1858070 mixed 3' read A
AI247115.1 Clone IMAGE:2004991 pancreas 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help