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UGID:141499     UniGene Hs.92236     Homo sapiens (human)   MLL4
Myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4)

Human protein-coding gene MLL4. Represented by 230 ESTs from 140 cDNA libraries. Corresponds to reference sequence NM_014727.1. [UniGene 141499 - Hs.92236]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_055542.1 MLL4 gene product H. sapiens 100.0 2714
XP_512597.3 PREDICTED: histone-lysine N-methyltransferase MLL4-like P. troglodytes 99.7 2525
NP_083550.2 Wbp7 gene product M. musculus 93.5 2712
XP_003200588.1 PREDICTED: histone-lysine N-methyltransferase MLL4-like D. rerio 77.6 436
NP_476770.1 trithorax, isoform B D. melanogaster 60.5 358
NP_001087630.1 histone-lysine N-methyltransferase SETD1B X. laevis 57.3 149
NP_498041.1 Protein SET-2, isoform b C. elegans 54.9 143
Other hits (2 of 50) [Show all]SpeciesId(%)Len(aa)
XP_003915410.1 PREDICTED: histone-lysine N-methyltransferase MLL4-like P. anubis 99.0 2715
XP_001112093.2 PREDICTED: histone-lysine N-methyltransferase MLL4-like M. mulatta 98.2 2687

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; mixed; uncharacterized tissue; embryonic tissue; ovary; lung; pituitary gland; eye; mammary gland; muscle; uterus; intestine; pancreas; skin; prostate; spleen; umbilical cord; kidney; mouth; blood; placenta; lymph node; larynx; connective tissue; liver; thymus; ascites; nerve; bone; heart; thyroid; adrenal gland
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19q13.1
UniSTS entry: Chr 19 MARC_2763-2764:991933378:3
UniSTS entry: Chr 19 ksks195
UniSTS entry: Chr 19 D19S705E
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AJ007041.1 Homo sapiens mRNA for trithorax homologue 2 P
NM_014727.1 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4), mRNA P
AF186605.1 Homo sapiens MLL2 protein mRNA, partial cds P
BC007353.2 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 4, mRNA (cDNA clone IMAGE:3616127), partial cds PA
BC009337.2 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 4, mRNA (cDNA clone IMAGE:4128272), partial cds PA
AK303252.1 Homo sapiens cDNA FLJ61754 complete cds
BC026861.1 Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 4, mRNA (cDNA clone IMAGE:3857450), with apparent retained intron PA
AF105280.1 Homo sapiens myeloid/lymphoid leukemia 2 (MLL2) mRNA, partial cds P
AF104918.1 Homo sapiens myeloid/lymphoid leukemia 2 (MLL2) mRNA, partial cds P
AB002302.3 Homo sapiens mRNA for KIAA0304 protein, partial cds P

EST sequences (10 of 230) [Show all sequences]

AA969026.1 Clone IMAGE:1579571 mixed 3' read P
AA976862.1 Clone IMAGE:1558741 lung 3' read A
AI041160.1 Clone IMAGE:1642618 testis 3' read A
AI076644.1 Clone IMAGE:1674745 mixed 3' read P
AI128683.1 Clone IMAGE:1691207 heart 3' read A
BX092828.1 Clone IMAGp998J12171_;_IMAGE:40564 brain P
AI265989.1 Clone IMAGE:1891784 placenta 3' read A
CB118374.1 Clone L8SCK0-18-D12 liver 5' read P
AI197783.1 Clone IMAGE:1859805 brain 3' read A
AI224839.1 Clone IMAGE:1858748 mixed 3' read A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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