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UGID:141327     UniGene Hs.89901     Homo sapiens (human)   PDE4A
Phosphodiesterase 4A, cAMP-specific (PDE4A)

Human protein-coding gene PDE4A. Represented by 106 ESTs from 65 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 141327 - Hs.89901]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001104777.1 PDE4A gene product H. sapiens 100.0 885
NP_899668.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 5 M. musculus 91.9 843
NP_001088310.1 phosphodiesterase 4A, cAMP-specific X. laevis 88.0 678
XP_700812.4 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A D. rerio 84.2 761
NP_726855.1 dunce, isoform A D. melanogaster 69.1 657
NP_871944.1 Protein PDE-4, isoform c C. elegans 63.1 578
Other hits (2 of 36) [Show all]SpeciesId(%)Len(aa)
XP_003914928.1 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1 P. anubis 98.9 885
XP_003954492.1 PREDICTED: LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A P. troglodytes 96.1 616

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; pancreas; muscle; uterus; mammary gland; amniotic fluid; ovary; liver; skin; larynx; eye; connective tissue; salivary gland; spleen; ganglia; testis; intestine; lung; embryonic tissue; mixed; prostate; blood; uncharacterized tissue; placenta; kidney; bone
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13.2
UniSTS entry: Chr 19 RH98678
UniSTS entry: Chr 19 G06567
UniSTS entry: Chr 19 PDE4A
UniSTS entry: Chr 19 PDE4A
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (18)

U97584.1 Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A1A (PDE4A) mRNA, complete cds P
U68532.1 Homo sapiens cyclic AMP specific phosphodiesterase RD1 (PDE4a) mRNA, complete cds P
AY266362.1 Homo sapiens phosphodiesterase isozyme 4 (PDE4) mRNA, partial cds P
NM_006202.2 Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 4, mRNA PA
AY593872.1 Homo sapiens cAMP-specific phosphodiesterase (PDE4A) mRNA, complete cds P
L20965.1 Human phosphodiesterase mRNA, complete cds P
AY618547.1 Homo sapiens cyclic AMP phosphodiesterase PDE4A11 (PDE4A) mRNA, partial cds, alternatively spliced P
AF073745.2 Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A10 (PDE4A) mRNA, complete cds P
U18087.1 Human 3',5'-cyclic AMP phosphodiesterase HPDE4A6 mRNA, complete cds P
U18088.1 Human 3',5'-cyclic AMP phosphodiesterase inactive splice variant HSPDE4A7A mRNA, complete cds P
BC019864.1 Homo sapiens phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila), mRNA (cDNA clone MGC:30168 IMAGE:4942336), complete cds PA
NM_001111309.1 Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 3, mRNA PA
NM_001111308.1 Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 2, mRNA PA
NM_001111307.1 Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 1, mRNA PA
S75213.1 type-IVA cyclic AMP specific phosphodiesterase HPDE4A [human, T-cells, mRNA Partial, 2319 nt] P
NM_001243121.1 Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 5, mRNA PA
M37744.1 Human cyclic AMP (cAMP)-specific phosphodiesterase mRNA, complete cds PA
BC038234.1 Homo sapiens phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila), mRNA (cDNA clone MGC:46146 IMAGE:5732341), complete cds PA

EST sequences (10 of 106) [Show all sequences]

AA962029.1 Clone IMAGE:1593849 kidney 3' read
AA975441.1 Clone IMAGE:1558164 lung 3' read A
AA994528.1 Clone IMAGE:1628989 mixed 3' read P
AI091017.1 Clone IMAGE:1689730 mixed 3' read
AI144143.1 Clone IMAGE:1704695 brain 3' read A
AI352523.1 Clone IMAGE:1946993 uncharacterized tissue 3' read PA
AI565489.1 Clone IMAGE:2214761 uterus 3' read A
AI658713.1 Clone IMAGE:2251823 prostate 3' read A
F26191.1 Clone s4000050G01 muscle A
F31164.1 Clone s4000109G05 muscle


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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