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UGID:6280406     UniGene Hs.744906     Homo sapiens (human)   WNK1
WNK lysine deficient protein kinase 1 (WNK1)

Human protein-coding gene WNK1. Represented by 1128 ESTs from 434 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 6280406 - Hs.744906]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001171914.1 WNK1 gene product H. sapiens 100.0 2641
NP_001171977.1 serine/threonine-protein kinase WNK1 P. troglodytes 99.8 2381
NP_001186013.1 Wnk1 gene product M. musculus 92.0 2634
NP_872075.2 Protein WNK-1, isoform b C. elegans 68.6 560
NP_649329.3 Wnk, isoform A D. melanogaster 67.9 542
XP_001690143.1 WNK protein kinase C. reinhardtii 63.3 277
XP_689656.5 PREDICTED: serine/threonine-protein kinase WNK1 D. rerio 61.8 2402
NP_200367.2 putative serine/threonine-protein kinase WNK11 A. thaliana 52.4 250
Other hits (2 of 47) [Show all]SpeciesId(%)Len(aa)
XP_001095845.1 PREDICTED: serine/threonine-protein kinase WNK1 isoform 3 M. mulatta 98.7 2383
XP_003905837.1 PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase WNK1 P. anubis 98.2 2834

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
cDNA Sources: brain; mixed; testis; uncharacterized tissue; placenta; lymph node; lung; intestine; kidney; skin; eye; mammary gland; embryonic tissue; liver; prostate; uterus; blood; pancreas; bone marrow; cervix; mouth; heart; ovary; parathyroid; connective tissue; thymus; thyroid; bladder; ear; trachea; larynx; spinal cord; bone; stomach; muscle; amniotic fluid; vascular; spleen; pharynx; lymph; adrenal gland; nerve; ganglia; pineal gland; ascites; adipose tissue; pituitary gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12p13.3
UniSTS entry: Chr 12 RH11028
UniSTS entry: Chr 12 D12S1913
UniSTS entry: Chr 12 RH78846 [Map Viewer]
UniSTS entry: Chr 12 G32902
UniSTS entry: Chr 12 SGC34797 [Map Viewer]
UniSTS entry: Chr 12 A009W04 [Map Viewer]
UniSTS entry: Chr 12 SHGC-36515
UniSTS entry: Chr 12 RH80475
UniSTS entry: Chr 12 G41016
UniSTS entry: Chr 12 SGC33532 [Map Viewer]
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (20)

BC044600.1 Homo sapiens cDNA clone IMAGE:4814776 A
AY231477.1 Homo sapiens lysine deficient 1-kinase defective isoform (PRKWNK1) mRNA, partial cds
NM_213655.4 Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 3, mRNA P
AJ296290.1 Homo sapiens mRNA for putative protein kinase (WNK1 gene) P
NM_018979.3 Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 1, mRNA P
BC130469.1 Homo sapiens hereditary sensory neuropathy, type II, mRNA (cDNA clone MGC:163341 IMAGE:40146500), complete cds P
BC130467.1 Homo sapiens hereditary sensory neuropathy, type II, mRNA (cDNA clone MGC:163339 IMAGE:40146498), complete cds P
BC141881.1 Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:40126884), partial cds P
DQ925672.1 Homo sapiens clone 3B-4 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced
DQ925671.1 Homo sapiens clone 2-1 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced
DQ925670.1 Homo sapiens clone 1B-2 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced
DQ925669.1 Homo sapiens clone 2A-3 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced
BC013629.2 Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:3445410), partial cds PA
AF061944.1 Homo sapiens kinase deficient protein KDP mRNA, partial cds P
BC035146.1 Homo sapiens cDNA clone IMAGE:5264735 A
U00946.1 Human clone A9A2BRB5 (CAC)n/(GTG)n repeat-containing mRNA
NM_014823.2 Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 2, mRNA P
NM_001184985.1 Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 4, mRNA P
JQ358908.1 Homo sapiens WNK lysine deficient protein kinase 1 isoform (WNK1) mRNA, complete cds, alternatively spliced P
AB002342.2 Homo sapiens mRNA for KIAA0344 gene, partial cds P

EST sequences (10 of 1128) [Show all sequences]

AA974227.1 Clone IMAGE:1585903 uncharacterized tissue 3' read A
R14789.1 Clone IMAGE:29980 brain 5' read
AA985685.1 Clone IMAGE:1601325 lung 3' read P
AA991835.1 Clone IMAGE:1619735 testis 3' read A
AI000971.1 Clone IMAGE:1609537 mammary gland 3' read
AI022912.1 Clone IMAGE:1651065 parathyroid 3' read A
R18919.1 Clone IMAGE:32637 brain 5' read
AI027598.1 Clone IMAGE:1645420 testis 3' read A
AA922122.1 Clone IMAGE:1544000 mixed 3' read A
R19400.1 Clone IMAGE:130007 mixed 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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