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UGID:5867145     UniGene Hs.740700     Homo sapiens (human)   MTHFD2L
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (MTHFD2L)

Human protein-coding gene MTHFD2L. Represented by 100 ESTs from 60 cDNA libraries. Corresponds to reference sequence NM_001144978.1. [UniGene 5867145 - Hs.740700]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001138450.1 MTHFD2L gene product H. sapiens 100.0 346
XP_517226.3 PREDICTED: probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 P. troglodytes 99.7 336
NP_081064.1 Mthfd2l gene product M. musculus 94.1 337
NP_001086806.1 methylenetetrahydrofolate dehydrogenase 2 X. laevis 76.2 307
XP_002662245.1 PREDICTED: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial-like D. rerio 74.6 319
NP_476930.1 NAD-dependent methylenetetrahydrofolate dehydrogenase, isoform A D. melanogaster 58.2 294
NP_009640.1 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 S. cerevisiae 50.0 186
NP_191971.1 Amino acid dehydrogenase family protein A. thaliana 48.3 288
XP_001703554.1 5,10-methylenetetrahydrofolate dehydrogenase C. reinhardtii 46.4 192
Other hits (2 of 48) [Show all]SpeciesId(%)Len(aa)
XP_001091218.2 PREDICTED: probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2-like M. mulatta 98.6 346
XP_003898808.1 PREDICTED: probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 P. anubis 98.3 350

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; liver; testis; uncharacterized tissue; pancreas; lung; mixed; embryonic tissue; thymus; intestine; vascular; connective tissue; uterus; prostate; kidney; blood; skin; bone marrow; lymph node; ovary
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4q13.3
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (5)

AK122799.1 Homo sapiens cDNA FLJ16372 fis, clone THYMU3000082, highly similar to BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR P
BC065771.1 Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like, mRNA (cDNA clone IMAGE:6102182), complete cds PA
BC032771.1 Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like, mRNA (cDNA clone IMAGE:3885359), complete cds PA
NM_001144978.1 Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (MTHFD2L), mRNA PA
BC041943.1 Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like, mRNA (cDNA clone IMAGE:5301277) A

EST sequences (10 of 100) [Show all sequences]

AA928156.1 Clone IMAGE:1563587 mixed 3' read
AI138322.1 Clone IMAGE:1736295 testis 3' read A
BX103541.1 Clone IMAGp998O164411_;_IMAGE:1736295 testis
BX090674.1 Clone IMAGp998G153580_;_IMAGE:1416998 lung A
AI218943.1 Clone IMAGE:1840741 mixed 3' read
AI219460.1 Clone IMAGE:1844555 mixed 3' read P
CB155135.1 Clone B2N807043-8-C07 brain 5' read
AA904261.1 Clone IMAGE:1417409 lung 3' read
AI368428.1 Clone IMAGE:2011397 brain 3' read A
AI376685.1 Clone IMAGE:2065999 embryonic tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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