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UGID:3354979     UniGene Hs.713539     Homo sapiens (human)   MAP3K12
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)

Human protein-coding gene MAP3K12. Represented by 107 ESTs from 80 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 3354979 - Hs.713539]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001180440.1 MAP3K12 gene product H. sapiens 100.0 891
XP_509099.3 PREDICTED: mitogen-activated protein kinase kinase kinase 12 P. troglodytes 99.9 859
XP_001105474.1 PREDICTED: mitogen-activated protein kinase kinase kinase 12 isoform 1 M. mulatta 99.5 889
XP_003906508.1 PREDICTED: mitogen-activated protein kinase kinase kinase 12 P. anubis 99.5 856
NP_033608.3 mitogen-activated protein kinase kinase kinase 12 M. musculus 98.2 887
NP_001094411.1 mitogen-activated protein kinase kinase kinase 12 X. laevis 81.3 803
NP_996977.1 map3k12 gene product D. rerio 79.5 847
NP_001189132.1 wallenda, isoform D D. melanogaster 65.8 506
NP_001021445.1 Protein DLK-1, isoform c C. elegans 53.6 375
Other hits (2 of 35) [Show all]SpeciesId(%)Len(aa)
XP_003126240.1 PREDICTED: mitogen-activated protein kinase kinase kinase 12 S. scrofa 99.0 891
XP_848815.1 PREDICTED: mitogen-activated protein kinase kinase kinase 12 isoform 2 C. lupus familiaris 98.8 892

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; stomach; uncharacterized tissue; lung; eye; ovary; embryonic tissue; mixed; kidney; skin; muscle; larynx; liver; placenta; nerve; pituitary gland; adrenal gland; connective tissue; thymus; uterus; intestine; thyroid; blood; mammary gland; testis; heart; tonsil; bone marrow; bone; prostate; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12q13
UniSTS entry: Chr 12 PMC87148P1
UniSTS entry: Chr 12 D12S2095
UniSTS entry: Chr 12 G15864
UniSTS entry: Chr 12 GDB:593999
UniSTS entry: Chr 1 D11S2921
UniSTS entry: Chr 1 D1S1425
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

BC050050.1 Homo sapiens mitogen-activated protein kinase kinase kinase 12, mRNA (cDNA clone MGC:42552 IMAGE:4824512), complete cds PA
NM_006301.3 Homo sapiens mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2, mRNA P
AB209453.1 Homo sapiens mRNA for mitogen-activated protein kinase kinase kinase 12 variant protein P
AK314530.1 Homo sapiens cDNA, FLJ95351 P
AK094195.1 Homo sapiens cDNA FLJ36876 fis, clone ASTRO2019171, highly similar to Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) P
AK094109.1 Homo sapiens cDNA FLJ36790 fis, clone ADRGL2004724
BC037585.1 Homo sapiens, clone IMAGE:5532846, mRNA P
U07358.1 Human protein kinase (zpk) mRNA, complete cds P
NM_001193511.1 Homo sapiens mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 1, mRNA P

EST sequences (10 of 107) [Show all sequences]

AA987909.1 Clone IMAGE:1605105 lung 3' read
AI066406.1 Clone IMAGE:1682059 skin 3' read PA
AI078836.1 Clone IMAGE:1678381 mixed 3' read A
BX095794.1 Clone IMAGp998K204270_;_IMAGE:1682059 skin P
AI191050.1 Clone IMAGE:1739985 lung 3' read P
AI217632.1 Clone IMAGE:1732469 heart 3' read A
AI703063.1 Clone IMAGE:2337989 lung 3' read P
AI769411.1 Clone IMAGE:2402715 kidney 3' read P
AI808782.1 Clone IMAGE:2363499 mixed 3' read A
AI808797.1 Clone IMAGE:2363523 mixed 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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