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UGID:131953     UniGene Hs.6764     Homo sapiens (human)   HDAC6
Histone deacetylase 6 (HDAC6)

Human protein-coding gene HDAC6. Represented by 678 ESTs from 222 cDNA libraries. Corresponds to reference sequence NM_006044.2. [UniGene 131953 - Hs.6764]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_006035.2 HDAC6 gene product H. sapiens 100.0 1214
XP_003917728.1 PREDICTED: histone deacetylase 6 isoform 3 P. anubis 99.5 1228
NP_034543.3 Hdac6 gene product M. musculus 86.8 1148
XP_693858.4 PREDICTED: histone deacetylase 6 D. rerio 61.4 1061
NP_001080486.1 histone deacetylase 6 X. laevis 59.3 1281
XP_001697497.1 histone deacetylase C. reinhardtii 58.7 222
NP_001162760.1 HDAC6, isoform D D. melanogaster 55.6 794
NP_200914.2 histone deacetylase 5 A. thaliana 53.6 360
XP_956974.2 hypothetical protein NCU01525 N. crassa 52.7 298
NP_500788.1 Protein HDA-6, isoform a C. elegans 51.0 716
NP_014377.1 Hda1p S. cerevisiae 48.7 263
Other hits (2 of 55) [Show all]SpeciesId(%)Len(aa)
XP_001101533.2 PREDICTED: histone deacetylase 6-like isoform 7 M. mulatta 99.4 1260
XP_003317503.2 PREDICTED: histone deacetylase 6 P. troglodytes 98.3 1217

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; embryonic tissue; uterus; uncharacterized tissue; liver; mixed; eye; thymus; stomach; intestine; blood; bone marrow; placenta; muscle; lung; heart; prostate; umbilical cord; cervix; pharynx; connective tissue; trachea; bladder; ovary; adrenal gland; ganglia; thyroid; skin; mammary gland; kidney; larynx; vascular; mouth; spleen; amniotic fluid; bone; esophagus; spinal cord; parathyroid; ascites; pituitary gland; lymph node; adipose tissue
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: X
Map position: Xp11.23
UniSTS entry: Chr X WI-8811 [Map Viewer]
UniSTS entry: Chr X DXS6992E [Map Viewer]
UniSTS entry: Chr X A002Y02 [Map Viewer]
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (19)

AJ011972.1 Homo sapiens mRNA for histone deacetylase-like protein (JM21) P
AB020708.1 Homo sapiens mRNA for KIAA0901 protein, partial cds P
BT006649.1 Homo sapiens histone deacetylase 6 mRNA, complete cds P
NM_006044.2 Homo sapiens histone deacetylase 6 (HDAC6), mRNA P
AK001543.1 Homo sapiens cDNA FLJ10681 fis, clone NT2RP3000031, highly similar to Histone deacetylase 6 P
AF174499.1 Homo sapiens GR AF-1 specific histone deacetylase mRNA, partial cds P
BC069243.1 Homo sapiens histone deacetylase 6, mRNA (cDNA clone MGC:78509 IMAGE:6584427), complete cds PA
AK131286.1 Homo sapiens cDNA FLJ16239 fis, clone HCASM2003099, highly similar to Histone deacetylase 6 PA
AF132609.1 Homo sapiens histone deacetylase 6 mRNA, complete cds P
AK024083.1 Homo sapiens cDNA FLJ14021 fis, clone HEMBA1002513, highly similar to Histone deacetylase 6 P
BC005872.1 Homo sapiens histone deacetylase 6, mRNA (cDNA clone IMAGE:3029555), complete cds PA
BC011498.1 Homo sapiens histone deacetylase 6, mRNA (cDNA clone IMAGE:4179066), complete cds PA
BC013737.1 Homo sapiens histone deacetylase 6, mRNA (cDNA clone MGC:5339 IMAGE:2984860), complete cds PA
AK309058.1 Homo sapiens cDNA, FLJ99099 P
AK095124.1 Homo sapiens cDNA FLJ37805 fis, clone BRSSN2001342, highly similar to Histone deacetylase 6 P
AK295884.1 Homo sapiens cDNA FLJ54798 complete cds, highly similar to Histone deacetylase 6 P
AK303012.1 Homo sapiens cDNA FLJ56624 complete cds, highly similar to Histone deacetylase 6 P
AK302926.1 Homo sapiens cDNA FLJ56474 complete cds, highly similar to Histone deacetylase 6 P
BC013219.1 Homo sapiens histone deacetylase 6, mRNA (cDNA clone IMAGE:4149706) PA

EST sequences (10 of 678) [Show all sequences]

AI003790.1 Clone IMAGE:1635217 kidney 3' read PA
AI031785.1 Clone IMAGE:1649964 parathyroid 3' read A
BX103526.1 Clone IMAGp998P16246_;_IMAGE:156159 mammary gland P
AI189405.1 Clone IMAGE:1722483 uterus 3' read
AI251472.1 Clone IMAGE:1977890 brain 3' read A
AI244919.1 Clone IMAGE:1867034 kidney 3' read A
R35161.1 Clone IMAGE:37339 brain 5' read
AI291686.1 Clone IMAGE:1894524 placenta 3' read A
T25299.1 Clone BL29-16 uncharacterized tissue P
T25300.1 Clone BL29-16 uncharacterized tissue

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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