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UGID:2723783     UniGene Hs.654465     Homo sapiens (human)   GCLC
Glutamate-cysteine ligase, catalytic subunit (GCLC)

Human protein-coding gene GCLC. Represented by 488 ESTs from 169 cDNA libraries. Corresponds to 2 reference sequences (different isoforms). [UniGene 2723783 - Hs.654465]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001155930.1 PREDICTED: glutamate--cysteine ligase catalytic subunit isoform 5 P. troglodytes 100.0 636
NP_001489.1 GCLC gene product H. sapiens 100.0 636
XP_001108943.1 PREDICTED: glutamate--cysteine ligase catalytic subunit isoform 3 M. mulatta 99.8 636
XP_003897796.1 PREDICTED: glutamate--cysteine ligase catalytic subunit isoform 1 P. anubis 99.8 636
NP_034425.1 Gclc gene product M. musculus 97.3 636
NP_001108242.1 glutamate-cysteine ligase, catalytic subunit X. laevis 91.3 636
NP_954971.2 gclc gene product D. rerio 88.8 630
NP_525005.2 Glutamate-cysteine ligase catalytic subunit, isoform A D. melanogaster 66.8 542
NP_495927.2 Protein GCS-1 C. elegans 60.6 624
XP_961523.1 glutamate-cysteine ligase catalytic subunit N. crassa 53.9 659
NP_012434.1 Gsh1p S. cerevisiae 51.1 493
Other hits (2 of 47) [Show all]SpeciesId(%)Len(aa)
XP_852845.1 PREDICTED: glutamate--cysteine ligase catalytic subunit isoform 1 C. lupus familiaris 98.7 636
XP_002714554.1 PREDICTED: glutamate-cysteine ligase, catalytic subunit O. cuniculus 98.4 636

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mammary gland; mouth; mixed; lung; liver; bladder; thyroid; bone marrow; spleen; trachea; uncharacterized tissue; testis; pancreas; embryonic tissue; kidney; placenta; prostate; blood; stomach; uterus; skin; intestine; lymph; esophagus; muscle; bone; thymus; ovary; larynx; ear; ascites; connective tissue; lymph node; nerve; parathyroid; adrenal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 6
Map position: 6p12
UniSTS entry: Chr 6 RH102364
UniSTS entry: Chr 6 SHGC-53188
UniSTS entry: Chr 6 D6S2060
UniSTS entry: Chr 6 STS-M90656
UniSTS entry: Gclc
UniSTS entry: Chr 1 D11S3114
UniSTS entry: Chr 6 G67294
UniSTS entry: RH68488
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (11)

BC047788.1 Homo sapiens, Similar to glutamate-cysteine ligase, catalytic subunit, clone IMAGE:6196502, mRNA PA
NM_001498.3 Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 1, mRNA P
M90656.1 Human gamma-glutamylcysteine synthetase (GCS) mRNA, complete cds PA
AB262176.1 Homo sapiens GCLC mRNA for glutamate-cysteine ligase, complete cds P
BC022487.1 Homo sapiens glutamate-cysteine ligase, catalytic subunit, mRNA (cDNA clone IMAGE:4814728), complete cds PA
AK313480.1 Homo sapiens cDNA, FLJ94028, Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC),mRNA P
AK094940.1 Homo sapiens cDNA FLJ37621 fis, clone BRCOC2013675 PA
AK304288.1 Homo sapiens cDNA FLJ58227 complete cds, highly similar to Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) P
AB516284.1 Homo sapiens GCLC mRNA for glutamate-cysteine ligase delta4 alternative splicing variant, complete cds P
NM_001197115.1 Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 2, mRNA P
BC039894.1 Homo sapiens glutamate-cysteine ligase, catalytic subunit, mRNA (cDNA clone MGC:47730 IMAGE:6052162), complete cds PA

EST sequences (10 of 488) [Show all sequences]

AA989375.1 Clone IMAGE:1607093 mammary gland 3' read P
AA992189.1 Clone IMAGE:1623096 embryonic tissue 3' read A
AI014488.1 Clone IMAGE:1607292 mammary gland 3' read
AI014626.1 Clone IMAGE:1628755 mixed 3' read A
AI075414.1 Clone IMAGE:1679361 skin 3' read
AI073631.1 Clone IMAGE:1665157 skin 3' read A
AI093285.1 Clone IMAGE:1695328 uterus 3' read A
CB046994.1 Clone IMAGE:3252785 kidney 3' read A
CB046995.1 Clone IMAGE:3252785 kidney 5' read
BX098409.1 Clone IMAGp998G15520_;_IMAGE:241958 mixed P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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