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UGID:2723776     UniGene Hs.654458     Homo sapiens (human)   IL6
Interleukin 6 (interferon, beta 2) (IL6)

Human protein-coding gene IL6. Represented by 145 ESTs from 61 cDNA libraries. EST representation biased toward adult. Corresponds to reference sequence NM_000600.3. [UniGene 2723776 - Hs.654458]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_518992.2 PREDICTED: interleukin-6 isoform 3 P. troglodytes 100.0 211
NP_000591.1 IL6 gene product H. sapiens 100.0 211
Other hits (2 of 7) [Show all]SpeciesId(%)Len(aa)
NP_001167007.1 IL6 gene product P. anubis 98.1 211
NP_001036198.1 interleukin-6 precursor M. mulatta 97.2 211

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: adult [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: lung; pancreas; connective tissue; eye; mixed; skin; uncharacterized tissue; amniotic fluid; placenta; kidney; bone; intestine; brain; vascular; spleen; ovary; blood; ascites; thymus; muscle; tonsil; lymph node
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 7
Map position: 7p21
UniSTS entry: Chr 7 D7S2743 [Map Viewer]
UniSTS entry: Chr 7 STS-M14584
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

CR450296.1 Homo sapiens full open reading frame cDNA clone RZPDo834C041D for gene IL6, interleukin 6 (interferon, beta 2); complete cds; without stopcodon P
BT019749.1 Homo sapiens interleukin 6 (interferon, beta 2) mRNA, complete cds P
BT019748.1 Homo sapiens interleukin 6 (interferon, beta 2) mRNA, complete cds P
M14584.1 Human interleukin 6 mRNA, complete cds P
M18403.1 Human hybridoma growth factor (interleukin 6) mRNA, complete cds P
M29150.1 Human interleukin 6 (B-cell stimulatory factor-2) mRNA, complete cds P
M54894.1 Human interleukin 6 mRNA, complete cds P
NM_000600.3 Homo sapiens interleukin 6 (interferon, beta 2) (IL6), mRNA PA
X04602.1 Human mRNA for interleukin BSF-2 (B-cell differentiation factor) P
BC015511.1 Homo sapiens interleukin 6 (interferon, beta 2), mRNA (cDNA clone MGC:9215 IMAGE:3884652), complete cds PA
AK301141.1 Homo sapiens cDNA FLJ61423 complete cds, highly similar to Interleukin-6 precursor P
AK298077.1 Homo sapiens cDNA FLJ52006 complete cds, moderately similar to Interleukin-6 precursor P
AK298013.1 Homo sapiens cDNA FLJ55231 complete cds, highly similar to Interleukin-6 precursor P
X04430.1 Human IFN-beta 2a mRNA for interferon-beta-2 P
X04403.1 Human mRNA fragment for inducible 26 kDa protein (C-terminus) in fibroblasts P
S56892.1 interleukin-6 [human, tonsillar mononuclear cells, mRNA, 657 nt] P

EST sequences (10 of 145) [Show all sequences]

AI074123.1 Clone IMAGE:1679146 skin 3' read A
AI095255.1 Clone IMAGE:1666237 skin 3' read A
AA947476.1 Clone IMAGE:1508411 mixed 3' read A
BX097268.1 Clone IMAGp998K15698_;_IMAGE:310406 skin P
AA911581.1 Clone IMAGE:1438771 lung 3' read A
AI085963.1 Clone IMAGE:1682257 skin 3' read A
AI343270.1 Clone IMAGE:2061996 intestine 3' read A
AI472218.1 Clone IMAGE:2148410 mixed 3' read A
AI632696.1 Clone IMAGE:2299865 kidney 3' read A
AI735329.1 Clone IMAGE:2354602 vascular 3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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