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UGID:2723765     UniGene Hs.654447     Homo sapiens (human)   CTSD
Cathepsin D (CTSD)

Human protein-coding gene CTSD. Represented by 1751 ESTs from 422 cDNA libraries. Corresponds to reference sequence NM_001909.4. [UniGene 2723765 - Hs.654447]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001900.1 CTSD gene product H. sapiens 100.0 411
NP_034113.1 Ctsd gene product M. musculus 88.8 409
NP_571785.1 ctsd gene product D. rerio 73.8 396
NP_001085308.1 cathepsin D precursor X. laevis 72.3 397
NP_510191.1 Protein ASP-4 C. elegans 61.3 364
NP_652013.1 cathD D. melanogaster 59.1 391
XP_001692331.1 pepsin-type aspartyl protease C. reinhardtii 57.7 260
NP_172655.1 aspartic proteinase A1 A. thaliana 55.4 307
XP_959917.1 vacuolar protease A precursor N. crassa 51.6 316
NP_015171.1 Pep4p S. cerevisiae 51.2 256
Other hits (2 of 61) [Show all]SpeciesId(%)Len(aa)
XP_001091601.1 PREDICTED: cathepsin D isoform 3 M. mulatta 98.1 411
NP_001162374.1 cathepsin D precursor P. anubis 98.1 411

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; lung; placenta; pancreas; skin; uncharacterized tissue; intestine; mammary gland; kidney; eye; stomach; mixed; testis; prostate; embryonic tissue; tonsil; bladder; salivary gland; ascites; blood; spleen; bone; larynx; uterus; thyroid; connective tissue; liver; ovary; lymph node; bone marrow; thymus; esophagus; parathyroid; cervix; adipose tissue; ganglia; adrenal gland; nerve; pharynx; muscle; lymph; pituitary gland; pineal gland; vascular; mouth
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 11
Map position: 11p15.5
UniSTS entry: Chr 11 MARC_10183-10184:1004371792:5
UniSTS entry: Chr 11 CTSD [Map Viewer]
UniSTS entry: Chr 11 REN61207
UniSTS entry: Chr 11 REN61206
UniSTS entry: Chr 11 ECD01139
UniSTS entry: Chr 11 REN61199
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

BT006910.1 Homo sapiens cathepsin D (lysosomal aspartyl protease) mRNA, complete cds P
AK130178.1 Homo sapiens cDNA FLJ26668 fis, clone MPG03026, highly similar to Cathepsin D precursor (EC P
NM_001909.4 Homo sapiens cathepsin D (CTSD), mRNA PA
M11233.1 Human cathepsin D mRNA, complete cds P
CR456947.1 Homo sapiens full open reading frame cDNA clone RZPDo834E1218D for gene CTSD, cathepsin D (lysosomal aspartyl protease); complete cds, incl. stopcodon P
BT020155.1 Homo sapiens cathepsin D (lysosomal aspartyl protease) mRNA, complete cds P
X05344.1 Human mRNA for cathepsin D from oestrogen responsive breast cancer cells P
BC016320.2 Homo sapiens cathepsin D, mRNA (cDNA clone MGC:2311 IMAGE:3506977), complete cds PA
BC001574.1 Homo sapiens cathepsin D, mRNA (cDNA clone IMAGE:3455250) PA

EST sequences (10 of 1751) [Show all sequences]

AA987393.1 Clone IMAGE:1593275 kidney 3' read A
AI003138.1 Clone IMAGE:1699938 kidney 3' read
AI025759.1 Clone IMAGE:1646535 parathyroid 3' read
AI031979.1 Clone IMAGE:1650792 parathyroid 3' read A
AI033610.1 Clone IMAGE:1646770 parathyroid 3' read
AI039839.1 Clone IMAGE:1663400 skin 3' read A
CA975896.1 Clone IMAGE:6202290 nerve 5' read P
CB044478.1 Clone IMAGE:3217737 intestine 5' read P
R24815.1 Clone IMAGE:35462 brain 5' read
AI167774.1 Clone IMAGE:1682572 parathyroid 3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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